Human epidermal stem cell function is regulated by circadian oscillations
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- dc.contributor.author Janich, Peggy, 1981-ca
- dc.contributor.author Toufighi, Kiana, 1980-ca
- dc.contributor.author Solanas, Guiomarca
- dc.contributor.author Luis, Nuno Miguel, 1982-ca
- dc.contributor.author Minkwitz, Susannca
- dc.contributor.author Serrano Pubull, Luis, 1982-ca
- dc.contributor.author Lehner, Ben, 1978-ca
- dc.contributor.author Aznar Benitah, Salvadorca
- dc.date.accessioned 2015-02-11T09:31:26Z
- dc.date.available 2015-02-11T09:31:26Z
- dc.date.issued 2013ca
- dc.description.abstract Human skin copes with harmful environmental factors that are circadian in nature, yet how circadian rhythms modulate the function of human epidermal stem cells is mostly unknown. Here we show that in human epidermal stem cells and their differentiated counterparts, core clock genes peak in a successive and phased manner, establishing distinct temporal intervals during the 24 hr day period. Each of these successive clock waves is associated with a peak in the expression of subsets of transcripts that temporally segregate the predisposition of epidermal stem cells to respond to cues that regulate their proliferation or differentiation, such as TGFβ and calcium. Accordingly, circadian arrhythmia profoundly affects stem cell function in culture and in vivo. We hypothesize that this intricate mechanism ensures homeostasis by providing epidermal stem cells with environmentally relevant temporal functional cues during the course of the day and that its perturbation may contribute to aging and carcinogenesis.
- dc.description.sponsorship This work has been funded by an ERC Consolidator Grant (STEMCLOCK) to S.A.B. and by the PROSPECTS, grant agreement number HEALTH-F4-2008-201648, to L.S. from the European Union. G.S. is funded by an AXA Fund fellowship. K.T. is funded by a La Caixa Ph.D. fellowship./nResearch in the lab of B.L. is funded by the European Research Council (ERC), MINECO Plan Nacional grant BFU2011-26206, ERASysBio+ ERANET project EUI2009-04059 GRAPPLE, the EMBO Young Investigator Program, EU Framework 7 project 277899 4DCellFate, and the EMBL/CRG Systems Biology Program
- dc.format.mimetype application/pdfca
- dc.identifier.citation Janich P, Toufighi K, Solanas G, Luis NM, Minkwitz S, Serrano L et al. Human epidermal stem cell function is regulated by circadian oscillations. Cell Stem Cell. 2013;13(6):745-53. DOI: 10.1016/j.stem.2013.09.004ca
- dc.identifier.doi http://dx.doi.org/10.1016/j.stem.2013.09.004
- dc.identifier.issn 1934-5909ca
- dc.identifier.uri http://hdl.handle.net/10230/23118
- dc.language.iso engca
- dc.publisher Elsevierca
- dc.relation.ispartof Cell Stem Cell. 2013;13(6):745-53
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/277899ca
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2011-26206
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/201648
- dc.rights © Elsevier http://dx.doi.org/10.1016/j.stem.2013.09.004 Article published under an Elsevier user license, protected by copyright and may be used for non-commercial purposes. Users may access, download, copy, translate, text mine and data mine the article.ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri http://www.elsevier.com/open-access/userlicense/1.0/
- dc.subject.other Ritmes circadiaris -- Efectes fisiològics
- dc.subject.other Epidermis -- Citologia
- dc.subject.other Cèl·lules mare -- Citologia
- dc.title Human epidermal stem cell function is regulated by circadian oscillationsca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca