Real-world evidence from a european cohort study of patients with treatment resistant depression: healthcare resource utilization
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- dc.contributor.author Heerlein, K.
- dc.contributor.author De Giorgi, S.
- dc.contributor.author Degraeve, G.
- dc.contributor.author Frodl, T.
- dc.contributor.author Hagedoorn, W.
- dc.contributor.author Oliveira Maia, A. J.
- dc.contributor.author Otte, C.
- dc.contributor.author Pérez Solá, Victor
- dc.contributor.author Rathod, S.
- dc.contributor.author Rosso, G.
- dc.contributor.author Sierra, Pablo
- dc.contributor.author Vita , A.
- dc.contributor.author Morrens, J.
- dc.contributor.author Rive, B.
- dc.contributor.author Mulhern Haughey S.
- dc.contributor.author Kambarov, Y.
- dc.contributor.author Young, Allan H.
- dc.date.accessioned 2022-09-06T07:16:42Z
- dc.date.available 2022-09-06T07:16:42Z
- dc.date.issued 2022
- dc.description.abstract Background: treatment resistant depression (TRD) is diagnosed when patients experiencing a major depressive episode fail to respond to ≥2 treatments. Along with substantial indirect costs, patients with TRD have higher healthcare resource utilization (HCRU) than other patients with depression. However, research on the economic impact of this HCRU, and differences according to response to treatment, is lacking. Methods: this multicenter, observational study documented HCRU among patients with TRD in European clinical practice initiating new antidepressant treatments. Data regarding access to outpatient consultations and other healthcare resources for the first 6 months, collected using a questionnaire, were analyzed qualitatively according to response and remission status. The economic impact of HCRU, estimated using European costing data, was analyzed quantitatively. Results: among 411 patients, average HCRU was higher in non-responders, attending five times more general practitioner (GP) consultations and spending longer in hospital (1.7 versus 1.1 days) than responders. Greater differences were observed according to remission status, with non-remitters attending seven times more GP consultations and spending approximately three times longer in hospital (1.7 versus 0.6 days) than remitters. Consequently, the estimated economic impacts of non-responders and non-remitters were significantly greater than those of responders and remitters, respectively. Limitations: key limitations are small cohort size, absence of control groups and generalizability to different healthcare systems. Conclusion: patients with TRD, particularly those not achieving remission, have considerable HCRU, with associated economic impact. The costs of unmet TRD treatment needs are thus substantial, and treatment success is fundamental to reduce individual needs and societal costs.
- dc.format.mimetype application/pdf
- dc.identifier.citation Heerlein K, De Giorgi S, Degraeve G, Frodl T, Hagedoorn W, Oliveira-Maia AJ, et al. Real-world evidence from a european cohort study of patients with treatment resistant depression: healthcare resource utilization. Disord. 2022 Feb 1; 298(Pt A): 442-450. DOI: 10.1016/j.jad.2021.11.004.
- dc.identifier.doi http://dx.doi.org/10.1016/j.jad.2021.11.004
- dc.identifier.issn 0165-0327
- dc.identifier.uri http://hdl.handle.net/10230/53995
- dc.language.iso eng
- dc.publisher Elsevier
- dc.rights 0165-0327/© 2021, Heerlein K, De Giorgi S, Degraeve G, Frodl T, Hagedoorn W, Oliveira-Maia AJ. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Healthcare resource utilization
- dc.subject.keyword Major depressive disorder
- dc.subject.keyword Observational study
- dc.subject.keyword Real-world evidence
- dc.subject.keyword Treatment resistant depression
- dc.title Real-world evidence from a european cohort study of patients with treatment resistant depression: healthcare resource utilization
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion