Cancer LncRNA census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis

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  • dc.contributor.author Carlevaro-Fita, Joana
  • dc.contributor.author Lanzós, Andrés
  • dc.contributor.author Feuerbach, Lars
  • dc.contributor.author Hong, Chen
  • dc.contributor.author Mas Ponte, David
  • dc.contributor.author Pedersen, Jackob S.
  • dc.contributor.author PCAWG Drivers and Functional Interpretation Working Group
  • dc.contributor.author Johnson, Rory
  • dc.contributor.author PCAWG Consortium
  • dc.date.accessioned 2020-03-17T07:33:50Z
  • dc.date.available 2020-03-17T07:33:50Z
  • dc.date.issued 2020
  • dc.description.abstract Long non-coding RNAs (lncRNAs) are a growing focus of cancer genomics studies, creating the need for a resource of lncRNAs with validated cancer roles. Furthermore, it remains debated whether mutated lncRNAs can drive tumorigenesis, and whether such functions could be conserved during evolution. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we introduce the Cancer LncRNA Census (CLC), a compilation of 122 GENCODE lncRNAs with causal roles in cancer phenotypes. In contrast to existing databases, CLC requires strong functional or genetic evidence. CLC genes are enriched amongst driver genes predicted from somatic mutations, and display characteristic genomic features. Strikingly, CLC genes are enriched for driver mutations from unbiased, genome-wide transposon-mutagenesis screens in mice. We identified 10 tumour-causing mutations in orthologues of 8 lncRNAs, including LINC-PINT and NEAT1, but not MALAT1. Thus CLC represents a dataset of high-confidence cancer lncRNAs. Mutagenesis maps are a novel means for identifying deeply-conserved roles of lncRNAs in tumorigenesis.
  • dc.description.sponsorship A.L. was supported by pre-doctoral fellowship FPU14/03371
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Carlevaro-Fita J, Lanzós A, Feuerbach L, Hong C, Mas-Ponte D, Pedersen JS et al. Cancer LncRNA census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis. Commun Biol. 2020 Feb 5; 3(1): 56. DOI: 10.1038/s42003-019-0741-7
  • dc.identifier.doi http://dx.doi.org/10.1038/s42003-019-0741-7
  • dc.identifier.issn 2399-3642
  • dc.identifier.uri http://hdl.handle.net/10230/43912
  • dc.language.iso eng
  • dc.publisher Nature Research
  • dc.relation.ispartof Communications Biology. 2020 Feb 5;3(1):56
  • dc.rights © 2020 Joana Carlevaro-Fita et al. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.other Càncer
  • dc.subject.other Genòmica
  • dc.subject.other Genòmica comparada
  • dc.title Cancer LncRNA census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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Articles (Center for Genomic Regulation (CRG))
Articles (Departament de Medicina i Ciències de la Vida)
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