Exploration of cannabis use and polygenic risk scores on the psychotic symptom progression of a FEP cohort

Segura, Àlex G.; Mané Santacana, Anna; Prohens, Llucia; Rodríguez, Natalia; Mezquida, Gisela; Cuesta, Manuel J.; Vieta, Eduard; Amoretti, Silvia; Lobo, Antonio; González-Pinto, Ana; Díaz-Caneja, Covadonga M.; Roldán Bejarano, Alexandra; Jiménez, Esther; Baeza, Immaculada; Legido, Teresa; Saiz-Ruiz, Jerónimo; Bernardo, Miquel; Mas, Sergi; PEPs Group

Exploration of cannabis use and polygenic risk scores on the psychotic symptom progression of a FEP cohort

Mostra el registre complet Registre parcial de l'ítem

dc.contributor.author Segura, Àlex G.
dc.contributor.author Mané Santacana, Anna
dc.contributor.author Prohens, Llucia
dc.contributor.author Rodríguez, Natalia
dc.contributor.author Mezquida, Gisela
dc.contributor.author Cuesta, Manuel J.
dc.contributor.author Vieta, Eduard
dc.contributor.author Amoretti, Silvia
dc.contributor.author Lobo, Antonio
dc.contributor.author González-Pinto, Ana
dc.contributor.author Díaz-Caneja, Covadonga M.
dc.contributor.author Roldán Bejarano, Alexandra
dc.contributor.author Jiménez, Esther
dc.contributor.author Baeza, Immaculada
dc.contributor.author Legido, Teresa
dc.contributor.author Saiz-Ruiz, Jerónimo
dc.contributor.author Bernardo, Miquel
dc.contributor.author Mas, Sergi
dc.contributor.author PEPs Group
dc.date.accessioned 2024-04-10T06:10:08Z
dc.date.available 2024-04-10T06:10:08Z
dc.date.issued 2023
dc.description.abstract Cannabis use is highly prevalent in first-episode psychosis (FEP) and plays a critical role in its onset and prognosis, but the genetic underpinnings promoting both conditions are poorly understood. Current treatment strategies for cannabis cessation in FEP are clearly inefficacious. Here, we aimed to characterize the association between cannabis-related polygenic risk scores (PRS) on cannabis use and clinical course after a FEP. A cohort of 249 FEP individuals were evaluated during 12 months. Symptom severity was measured with the Positive and Negative Severity Scale and cannabis use with the EuropASI scale. Individual PRS for lifetime cannabis initiation (PRSCI) and cannabis use disorder (PRSCUD) were constructed. Current cannabis use was associated with increased positive symptoms. Cannabis initiation at younger ages conditioned the 12-month symptom progression. FEP patients with higher cannabis PRSCUD reported increased baseline cannabis use. PRSCI was associated with the course of negative and general symptomatology over follow-up. Cannabis use and symptom progression after a FEP were modulated by cannabis PRS, suggesting that lifetime initiation and use disorders may have partially independent genetic factors. These exploratory results may be the first step to identify those FEP patients more vulnerable to cannabis use and worse outcomes to ultimately develop tailored treatments.
dc.format.mimetype application/pdf
dc.identifier.citation Segura AG, Mané A, Prohens L, Rodriguez N, Mezquida G, Cuesta MJ, et al. Exploration of cannabis use and polygenic risk scores on the psychotic symptom progression of a FEP cohort. Psychiatry Res. 2023 Jul;325:115249. DOI: 10.1016/j.psychres.2023.115249
dc.identifier.doi http://dx.doi.org/10.1016/j.psychres.2023.115249
dc.identifier.issn 0165-1781
dc.identifier.uri http://hdl.handle.net/10230/59714
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Psychiatry Res. 2023 Jul;325:115249
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
dc.subject.keyword Cannabis
dc.subject.keyword Genetics
dc.subject.keyword Polygenic risk score
dc.subject.keyword Psychosis
dc.subject.keyword Schizophrenia
dc.title Exploration of cannabis use and polygenic risk scores on the psychotic symptom progression of a FEP cohort
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

Col·leccions

Articles (Hospital del Mar Research Institute)