Mapping brain state-dependent sensory responses across the mouse cortex

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  • dc.contributor.author Montagni, Elena
  • dc.contributor.author Resta, Francesco
  • dc.contributor.author Tort-Colet, Núria
  • dc.contributor.author Scaglione, Alessandro
  • dc.contributor.author Mazzamuto, Giacomo
  • dc.contributor.author Destexhe, Alain
  • dc.contributor.author Pavone, Francesco Saverio
  • dc.contributor.author Allegra Mascaro, Anna Letizia
  • dc.date.accessioned 2025-06-04T06:19:32Z
  • dc.date.available 2025-06-04T06:19:32Z
  • dc.date.issued 2024
  • dc.description.abstract Sensory information must be integrated across a distributed brain network for stimulus processing and perception. Recent studies have revealed specific spatiotemporal patterns of cortical activation for the early and late components of sensory-evoked responses, which are associated with stimulus features and perception, respectively. Here, we investigated how the brain state influences the sensory-evoked activation across the mouse cortex. We utilized isoflurane to modulate the brain state and conducted wide-field calcium imaging of Thy1-GCaMP6f mice to monitor distributed activation evoked by multi-whisker stimulation. Our findings reveal that the level of anesthesia strongly shapes the spatiotemporal features and the functional connectivity of the sensory-activated network. As anesthesia levels decrease, we observe increasingly complex responses, accompanied by the emergence of the late component within the sensory-evoked response. The persistence of the late component under anesthesia raises new questions regarding the potential existence of perception during unconscious states.
  • dc.description.sponsorship This work has been funded by the European Community (Human Brain Project, H2020–785907 and H2020-945539). In addition, this project has been supported by the Italian Ministry for Universities and Research, project THE Tuscany Health Ecosystem ECS_00000017 MUR_ PNRR, and in the framework of Eurobioimaging (ESFRI research infrastructure) - Advanced Light Microscopy Italian Node. The study was supported by the European Union's Horizon 2020 Framework Programme for Research and Innovation under grant agreement no. 654148 Laserlab-Europe.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Montagni E, Resta F, Tort-Colet N, Scaglione A, Mazzamuto G, Destexhe A, et al. Mapping brain state-dependent sensory responses across the mouse cortex. iScience. 2024 Apr 9;27(5):109692. DOI: 10.1016/j.isci.2024.109692
  • dc.identifier.doi http://dx.doi.org/10.1016/j.isci.2024.109692
  • dc.identifier.issn 2589-0042
  • dc.identifier.uri http://hdl.handle.net/10230/70606
  • dc.language.iso eng
  • dc.publisher Elsevier
  • dc.relation.ispartof iScience. 2024 Apr 9;27(5):109692
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/785907
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/945539
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/654148
  • dc.rights © 2024 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
  • dc.subject.keyword Neuroscience
  • dc.subject.keyword Sensory neuroscience
  • dc.title Mapping brain state-dependent sensory responses across the mouse cortex
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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