Cancer-associated fibroblast and M2 macrophage markers together predict outcome in colorectal cancer patients

Herrera, Mercedes; Herrera, Alberto; Domínguez, Gemma; Silva, Javier; García, Vanesa; García, Jose M.; Gómez, Irene; Soldevilla, Beatriz; Muñoz, Concepción; Provencio, Mariano; Campos Martin, Yolanda; García de Herreros, Antonio; Casal, José Ignacio; Bonilla, Félix; Peña, Cristina

Cancer-associated fibroblast and M2 macrophage markers together predict outcome in colorectal cancer patients

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dc.contributor.author Herrera, Mercedesca
dc.contributor.author Herrera, Albertoca
dc.contributor.author Domínguez, Gemmaca
dc.contributor.author Silva, Javierca
dc.contributor.author García, Vanesaca
dc.contributor.author García, Jose M.ca
dc.contributor.author Gómez, Ireneca
dc.contributor.author Soldevilla, Beatrizca
dc.contributor.author Muñoz, Concepciónca
dc.contributor.author Provencio, Marianoca
dc.contributor.author Campos Martin, Yolandaca
dc.contributor.author García de Herreros, Antonioca
dc.contributor.author Casal, José Ignacioca
dc.contributor.author Bonilla, Félixca
dc.contributor.author Peña, Cristinaca
dc.date.accessioned 2015-11-25T13:41:59Z
dc.date.available 2015-11-25T13:41:59Z
dc.date.issued 2013
dc.description.abstract Tumor epithelial cells within a tumor coexist with a complex microenvironment in which a variety of interactions between its various components determine the behavior of the primary tumors. Cancer-associated fibroblasts (CAF) and M2 macrophages, characterized by high expression of different markers, including α-SMA, FSP1 and FAP, or CD163 and DCSIGN, respectively, are involved in the malignancy of different tumors. In the present study, expression of the above markers in CAF and M2 macrophages was analyzed using RT-PCR and immunohistochemistry in the normal mucosa and tumor tissue from a cohort of 289 colorectal cancer patients. Expression of CAF and M2 markers is associated with the clinical outcome of colorectal cancer patients. Moreover, the combination of CAF and M2 markers identifies three groups of patients with clear differences in the progression of the disease. This combined variable could be a decisive factor in the survival of advanced-stage patients. Taken together, these analyses demonstrate the prognostic involvement of interrelationships between DCSIGN, CD163, α-SMA, FSP1 and FAP markers in the survival of colon cancer patients.ca
dc.format.mimetype application/pdfca
dc.identifier.citation Herrera M, Herrera A, Domínguez G, Silva J, García V, García JM et al. Cancer-associated fibroblast and M2 macrophage markers together predict outcome in colorectal cancer patients. Cancer science. 2013; 104(4): 437-444. DOI 10.1111/cas.12096ca
dc.identifier.doi http://dx.doi.org/10.1111/cas.12096
dc.identifier.issn 1347-9032
dc.identifier.uri http://hdl.handle.net/10230/25212
dc.language.iso engca
dc.publisher Japanese Cancer Associationca
dc.relation.ispartof Cancer science. 2013; 104(4): 437-444
dc.rights.accessRights info:eu-repo/semantics/openAccessca
dc.subject.other Tumors
dc.subject.other Prognosi
dc.title Cancer-associated fibroblast and M2 macrophage markers together predict outcome in colorectal cancer patientsca
dc.type info:eu-repo/semantics/articleca
dc.type.version info:eu-repo/semantics/publishedVersionca

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