Genomic analysis of the blood attributed to Louis XVI (1754–1793), king of France

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  • dc.contributor.author Olalde Marquínez, Íñigo, 1987-ca
  • dc.contributor.author Sánchez Quinto, Federico A, 1985-ca
  • dc.contributor.author Datta, Debayanca
  • dc.contributor.author Marigorta, Urko M.ca
  • dc.contributor.author Chiang, Charleston W.K.ca
  • dc.contributor.author Rodríguez, Juan Antonioca
  • dc.contributor.author Fernández Callejo, Marcosca
  • dc.contributor.author González Navarrete, Irene, 1983-ca
  • dc.contributor.author Montfort, Magdaca
  • dc.contributor.author Matas Lalueza, Lauraca
  • dc.contributor.author Civit, Sergica
  • dc.contributor.author Luiselli, Donataca
  • dc.contributor.author Charlier, Philippeca
  • dc.contributor.author Pettener, Davideca
  • dc.contributor.author Ramírez, Oscarca
  • dc.contributor.author Navarro i Cuartiellas, Arcadi, 1969-ca
  • dc.contributor.author Himmelbauer, Heinzca
  • dc.contributor.author Marquès i Bonet, Tomàs, 1975-ca
  • dc.contributor.author Lalueza Fox, Carles, 1965-ca
  • dc.date.accessioned 2015-06-19T07:18:40Z
  • dc.date.available 2015-06-19T07:18:40Z
  • dc.date.issued 2014ca
  • dc.description.abstract A pyrographically decorated gourd, dated to the French Revolution period, has been alleged to contain a handkerchief dipped into the blood of the French king Louis XVI (1754–1793) after his beheading but recent analyses of living males from two Bourbon branches cast doubts on its authenticity. We sequenced the complete genome of the DNA contained in the gourd at low coverage (2.5×) with coding sequences enriched at a higher 7.3× coverage. We found that the ancestry of the gourd's genome does not seem compatible with Louis XVI's known ancestry. From a functional perspective, we did not find an excess of alleles contributing to height despite being described as the tallest person in Court. In addition, the eye colour prediction supported brown eyes, while Louis XVI had blue eyes. This is the first draft genome generated from a person who lived in a recent historical period; however, our results suggest that this sample may not correspond to the alleged king.en
  • dc.description.sponsorship This work is supported by FEDER and Spanish Government grants BFU2012-38236 and the Spanish Multiple Sclerosis Netowrk (REEM) of the Instituto de Salud Carlos III (RD12/0032/0011) to A.N., BFU2011-28549 and ERC Starting Grant (260372) to T.M.-B. and BFU2012-34157 to C.L.-F. and S.C., and a predoctoral fellowship from the Basque Government (DEUI) to I.Oen
  • dc.format.mimetype application/pdfca
  • dc.identifier.citation Olalde I, Sánchez-Quinto F, Datta D, Marigorta UM, Chiang CWK, Rodríguez JA et al. Genomic analysis of the blood attributed to Louis XVI (1754–1793), king of France. Scientific Reports. 2014;4:4666. DOI: 10.1038/srep04666ca
  • dc.identifier.doi http://dx.doi.org/10.1038/srep04666
  • dc.identifier.issn 2045-2322ca
  • dc.identifier.uri http://hdl.handle.net/10230/24544
  • dc.language.iso engca
  • dc.publisher Nature Publishing Groupca
  • dc.relation.ispartof Scientific Reports. 2014;4:4666
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/260372
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2011-28549
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2012-38236
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2012-34157
  • dc.rights © Nature Publishing Group. This work is licensed under a Creative Commons Attribution 3.0 Unported License. The images in this article are included in the article's Creative Commons license, unless indicated otherwise in the image credit; if the image is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the imageca
  • dc.rights.accessRights info:eu-repo/semantics/openAccessca
  • dc.rights.uri http://creativecommons.org/licenses/by/3.0/
  • dc.subject.keyword Anthropologyen
  • dc.subject.keyword Genomicsen
  • dc.subject.other Genoma humà -- Històriaca
  • dc.title Genomic analysis of the blood attributed to Louis XVI (1754–1793), king of Franceen
  • dc.type info:eu-repo/semantics/articleca
  • dc.type.version info:eu-repo/semantics/publishedVersionca

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