Associations between ultra-processed food consumption and kidney function in an older adult population with metabolic syndrome

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• dc.contributor.author Valle-Hita, Cristina
• dc.contributor.author Díaz López, Andrés
• dc.contributor.author Becerra-Tomás, Nerea
• dc.contributor.author Toledo, Estefania
• dc.contributor.author Cornejo-Pareja, Isabel
• dc.contributor.author Abete, Itziar
• dc.contributor.author Sureda Gomila, Antoni
• dc.contributor.author Bes-Rastrollo, Maira
• dc.contributor.author Martínez, José Alfredo
• dc.contributor.author Tinahones Madueño, Francisco José
• dc.contributor.author Tur, Josep A.
• dc.contributor.author Garcidueñas-Fimbres, Tany E.
• dc.contributor.author París-Pallejá, Francisco
• dc.contributor.author Goday Arno, Alberto
• dc.contributor.author Goñi-Ruiz, Nuria
• dc.contributor.author Salas Salvadó, Jordi
• dc.contributor.author Babio, Nancy
• dc.date.accessioned 2024-05-07T06:58:24Z
• dc.date.available 2024-05-07T06:58:24Z
• dc.date.issued 2023
• dc.description.abstract Background & aims: Ultra-processed food (UPF) consumption has increased dramatically over the last decades worldwide. Although it has been linked to some cardiometabolic comorbidities, there is limited evidence regarding kidney function. This study aimed to cross-sectionally and longitudinally assess the association between UPF consumption and estimated-glomerular filtration rate (eGFR) based on Cystatin C (CysC). Methods: Older adults (mean age 65 ± 5.0 years, 46% women) with overweight/obesity and metabolic syndrome (MetS) who had available data of CysC at baseline (n = 1909), at one-year and at 3-years of follow-up (n = 1700) were analyzed. Food consumption was assessed using a validated 143-item semi-quantitative food frequency questionnaire and UPF consumption (% of g/d) at baseline and changes after one-year of follow-up were estimated according to NOVA classification system. Multivariable-adjusted linear and logistic regression models were performed to evaluate the cross-sectional associations between UPF consumption with eGFR levels and decreased kidney function (eGFR <60 ml/min/1.73 m2) at baseline. Multivariable-adjusted mixed-effects linear regression models were fitted to investigate the associations between one-year changes in UPF and eGFR over 3-years of follow-up. Results: Individuals with the highest baseline UPF consumption showed lower eGFR (β: -3.39 ml/min/1.73 m2; 95% CI: -5.59 to -1.20) and higher odds of decreased kidney function (OR: 1.64; 95% CI: 1.21 to 2.22) at baseline, compared to individuals in the lowest tertile. Participants in the highest tertile of one-year changes in UPF consumption presented a significant decrease in eGFR after one-year of follow-up (β: -1.45 ml/min/1.73 m2; 95% CI: -2.90 to -0.01) as well as after 3-years of follow-up (β: -2.18 ml/min/1.73 m2; 95% CI: -3.71 to -0.65) compared to those in the reference category. Conclusions: In a Mediterranean population of older adults with overweight/obesity and MetS, higher UPF consumption at baseline and one-year changes towards higher consumption of UPF were associated with worse kidney function at baseline and over 3-years of follow-up, respectively. Clinical trial registry number: ISRCTN89898870.
• dc.description.sponsorship This work was supported by the official Spanish Institutions for funding scientific biomedical research, CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN) and Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (six coordinated FIS projects leaded by JS-S and Jesús Vioque, including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532, PI20/00456, PI20/00339, PI20/00557, PI20/00886, PI20/01158); the Especial Action Project entitled: Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus grant to JS-S; the European Research Council (Advanced Research Grant 2014–2019; agreement #340918) granted to Miguel Ángel Martínez-González.; the Recercaixa (number 2013ACUP00194) grant to JS-S and NB; grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013, PS0358/2016, PI0137/2018); the PROMETEO/2017/017 grant from the Generalitat Valenciana; the SEMERGEN grant; the Boosting young talent call grant program for the development of IISPV research projects 2019–2021 (Ref.: 2019/IISPV/03 grant to AD-L); the Societat Catalana d'Endocrinologia i Nutrició (SCEN) Clinical-Research Grant 2019 (IPs: JS-S and AD-L). Collaborative Nutrition and/or Obesity Project for Young Researchers 2019 supported by CIBEROBN entitled: Lifestyle Interventions and Chronic Kidney Disease: Inflammation, Oxidative Stress and Metabolomic Profile (LIKIDI study) grant to AD-L. Jordi Salas-Salvadó, gratefully acknowledges the financial support by ICREA under the ICREA Academia programme. C.V–H. received a predoctoral grant from the Generalitat de Catalunya (2022 FI_B100108). TEG-F. received a grant from Government of Mexico (grant number 769789). AD-L received a Serra Hunter Fellowship from Generalitat de Catalunya. None of the funding sources took part in the design, collection, analysis, interpretation of the data, or writing the report, or in the decision to submit the manuscript for publication.
• dc.format.mimetype application/pdf
• dc.identifier.citation Valle-Hita C, Díaz-López A, Becerra-Tomás N, Toledo E, Cornejo-Pareja I, Abete I, et al. Associations between ultra-processed food consumption and kidney function in an older adult population with metabolic syndrome. Clin Nutr. 2023 Dec;42(12):2302-10. DOI: 10.1016/j.clnu.2023.09.028
• dc.identifier.doi http://dx.doi.org/10.1016/j.clnu.2023.09.028
• dc.identifier.issn 0261-5614
• dc.identifier.uri http://hdl.handle.net/10230/60050
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Clin Nutr. 2023 Dec;42(12):2302-10
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/340918
• dc.rights © 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword Cystatin C
• dc.subject.keyword Glomerular filtration rate
• dc.subject.keyword Kidney function decline
• dc.subject.keyword Ultra-processed food
• dc.title Associations between ultra-processed food consumption and kidney function in an older adult population with metabolic syndrome
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion