COVID-19 in grade 4-5 chronic kidney disease patients

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• dc.contributor.author Collado Nieto, Silvia
• dc.contributor.author Arenas Jiménez, María Dolores
• dc.contributor.author Barbosa Puig, Francisco
• dc.contributor.author Cao Baduell, Higinio
• dc.contributor.author Montero, Maria Milagro
• dc.contributor.author Villar García, Judit
• dc.contributor.author Barrios Barrera, Clara
• dc.contributor.author Rodriguez García, Eva
• dc.contributor.author Sans Atxer, Laia
• dc.contributor.author Sierra Ochoa, Adriana
• dc.contributor.author Pérez-Sáez, María José
• dc.contributor.author Redondo Pachón, María Dolores
• dc.contributor.author Coca, Armando
• dc.contributor.author Maiques Llácer, José María
• dc.contributor.author Güerri Fernández, Roberto
• dc.contributor.author Horcajada Gallego, Juan Pablo
• dc.contributor.author Crespo Barrio, Marta
• dc.contributor.author Pascual Santos, Julio
• dc.date.accessioned 2021-11-26T07:33:15Z
• dc.date.available 2021-11-26T07:33:15Z
• dc.date.issued 2020
• dc.description.abstract Introduction: Chronic kidney disease (CKD) increases the risk of mortality during coronavirus disease 2019 (COVID-19) episodes, and some reports have underlined the high incidence and severity of this infection in dialysis patients. Information on COVID-19 in nondialysis CKD patients is not available yet. Case reports: Here we present 7 patients with grade 4-5 CKD who developed symptomatic COVID-19; they comprise 2.6% of our 267 advanced CKD patients. The estimated GFR was between 12 and 20 mL/min during the month prior to COVID-19. The 3 major symptoms were fever, cough, and dyspnea, and 5 patients showed bilateral pneumonia. Hydroxychloroquine, azithromycin, ceftriaxone, and steroids were the most frequently prescribed drugs. Two patients needed noninvasive mechanical ventilation. All patients showed minimal to moderate kidney function deterioration during admission, with an eGFR decline below 5 mL/min in 6 cases. No patient required acute dialysis. Six patients were discharged alive and remained dialysis free athe t the time of reporting, and one 76-year-old patient died. Conclusions: COVID-19 affects grade 4-5 CKD patients, but prognosis may be acceptable if prompt supportive measures are applied. These findings should be confirmed in larger cohorts, and further observations will be needed to understand the full spectrum of clinical features and the optimal approach to COVID-19 in patients with advanced CKD.
• dc.format.mimetype application/pdf
• dc.identifier.citation Collado S, Arenas MD, Barbosa F, Cao H, Montero MM, Villar-García J, et al. COVID-19 in grade 4-5 chronic kidney disease patients. Kidney Blood Press Res. 2020; 45(5): 768-74. DOI: 10.1159/000511082
• dc.identifier.doi http://dx.doi.org/10.1159/000511082
• dc.identifier.issn 1420-4096
• dc.identifier.uri http://hdl.handle.net/10230/49066
• dc.language.iso eng
• dc.publisher Karger (S. Karger AG)
• dc.rights This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND) http://creativecommons.org/licenses/by-nc/4.0/ http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes as well as any distribution of modified material requires written permission.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
• dc.subject.keyword COVID-19
• dc.subject.keyword Chronic kidney disease
• dc.subject.keyword Pneumonia
• dc.subject.keyword SARS-CoV-2
• dc.title COVID-19 in grade 4-5 chronic kidney disease patients
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion