Satellite cells and markers of muscle regeneration during unloading and reloading: effects of treatment with resveratrol and curcumin
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- dc.contributor.author Mañas García, Laura, 1991-
- dc.contributor.author Guitart, Maria
- dc.contributor.author Duran Jordà, Xavier, 1974-
- dc.contributor.author Barreiro Portela, Esther
- dc.date.accessioned 2020-10-20T06:35:27Z
- dc.date.available 2020-10-20T06:35:27Z
- dc.date.issued 2020
- dc.description.abstract We hypothesized that treatment with pharmacological agents known to increase sirtuin-1 activity (resveratrol and curcumin) may enhance muscle regeneration. In limb muscles of mice (C57BL/6J, 10 weeks) exposed to reloading for seven days following a seven-day period of hindlimb immobilization with/without curcumin or resveratrol treatment, progenitor muscle cell numbers (FACS), satellite cell subtypes (histology), early and late muscle regeneration markers, phenotype and morphometry, sirtuin-1 activity and content, and muscle function were assessed. Treatment with either resveratrol or curcumin in immobilized muscles elicited a significant improvement in numbers of progenitor, activated, quiescent, and total counts of muscle satellite cells, compared to non-treated animals. Treatment with either resveratrol or curcumin in reloaded muscles compared to non-treated mice induced a significant improvement in the CSA of both hybrid (curcumin) and fast-twitch fibers (resveratrol), sirtuin-1 activity (curcumin), sirtuin-1 content (resveratrol), and counts of progenitor muscle cells (resveratrol). Treatment with the pharmacological agents resveratrol and curcumin enhanced the numbers of satellite cells (muscle progenitor, quiescent, activated, and total satellite cells) in the unloaded limb muscles but not in the reloaded muscles. These findings have potential clinical implications as treatment with these phenolic compounds would predominantly be indicated during disuse muscle atrophy to enhance the muscle regeneration process.
- dc.format.mimetype application/pdf
- dc.identifier.citation Mañas-García L, Guitart M, Duran X, Barreiro E. Satellite cells and markers of muscle regeneration during unloading and reloading: effects of treatment with resveratrol and curcumin. Nutrients. 2020 Jun 23; 12(6):1870. DOI: 10.3390/nu12061870
- dc.identifier.doi http://dx.doi.org/10.3390/nu12061870
- dc.identifier.issn 2072-6643
- dc.identifier.uri http://hdl.handle.net/10230/45520
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof Nutrients. 2020 Jun 23;12(6):1870
- dc.rights Copyright © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Activated satellite cells
- dc.subject.keyword Muscle progenitor cells
- dc.subject.keyword Muscle regeneration markers
- dc.subject.keyword Muscle reloading
- dc.subject.keyword Muscle unloading
- dc.subject.keyword Quiescent satellite cells
- dc.subject.keyword Sirtuin-1
- dc.title Satellite cells and markers of muscle regeneration during unloading and reloading: effects of treatment with resveratrol and curcumin
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion