MetaPhOrs 2.0: integrative, phylogeny-based inference of orthology and paralogy across the tree of life

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  • dc.contributor.author Chorostecki, Uciel
  • dc.contributor.author Molina, Manuel
  • dc.contributor.author Pryszcz, Leszek Piotr, 1985-
  • dc.contributor.author Gabaldón Estevan, Juan Antonio, 1973-
  • dc.date.accessioned 2020-05-13T07:14:18Z
  • dc.date.available 2020-05-13T07:14:18Z
  • dc.date.issued 2020
  • dc.description.abstract Inferring homology relationships across genes in different species is a central task in comparative genomics. Therefore, a large number of resources and methods have been developed over the years. Some public databases include phylogenetic trees of homologous gene families which can be used to further differentiate homology relationships into orthology and paralogy. MetaPhOrs is a web server that integrates phylogenetic information from different sources to provide orthology and paralogy relationships based on a common phylogeny-based predictive algorithm and associated with a consistency-based confidence score. Here we describe the latest version of the web server which includes major new implementations and provides orthology and paralogy relationships derived from ∼8.2 million gene family trees-from 13 different source repositories across ∼4000 species with sequenced genomes. MetaPhOrs server is freely available, without registration, at http://orthology.phylomedb.org/.
  • dc.description.sponsorship H2020 Marie Skłodowska-Curie Actions [H2020-MSCA-IF-2017-793699 to U.C.]; Spanish Ministry of Economy, Industry, and Competitiveness (MEIC) [PGC2018-099921-B-I00]; CERCA Programme/Generalitat de Catalunya; Catalan Research Agency (AGAUR) SGR423; European Union's Horizon 2020 Research and Innovation Programme [ERC-2016-724173]; INB [PT17/0009/0023 - ISCIII-SGEFI/ERDF to T.G.]. Funding for open access charge: H2020Grant.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Chorostecki U, Molina M, Pryszcz LP, Gabaldón T. MetaPhOrs 2.0: integrative, phylogeny-based inference of orthology and paralogy across the tree of life. Nucleic Acids Res. 2020; 48(W1):W553-W557. DOI: 10.1093/nar/gkaa282
  • dc.identifier.doi http://dx.doi.org/10.1093/nar/gkaa282
  • dc.identifier.issn 0305-1048
  • dc.identifier.uri http://hdl.handle.net/10230/44513
  • dc.language.iso eng
  • dc.publisher Oxford University Press
  • dc.relation.ispartof Nucleic Acids Res. 2020; 48(W1):W553-W557
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/793699
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PGC2018-099921-B-I00
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/724173
  • dc.rights © The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
  • dc.title MetaPhOrs 2.0: integrative, phylogeny-based inference of orthology and paralogy across the tree of life
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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