Serum selenium and incident cardiovascular disease in the PREvención con DIeta MEDiterránea (PREDIMED) trial: Nested case-control study

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• dc.contributor.author Gutiérrez Bedmar, Mario
• dc.contributor.author Gil, Fernando
• dc.contributor.author Olmedo, Pablo
• dc.contributor.author Ruiz-Canela, Miguel
• dc.contributor.author Martínez-González, Miguel Ángel, 1957-
• dc.contributor.author Salas Salvadó, Jordi
• dc.contributor.author Babio, Nancy
• dc.contributor.author Fitó Colomer, Montserrat
• dc.contributor.author Val, José Luis del
• dc.contributor.author Corella, Dolores
• dc.contributor.author Sorlí, José Vicente
• dc.contributor.author Ros, Emilio
• dc.contributor.author Fiol, Miquel
• dc.contributor.author Estruch, Ramón
• dc.contributor.author Santos-Lozano, José
• dc.contributor.author Arós, Fernando
• dc.contributor.author Serra Majem, Lluís
• dc.contributor.author Pintó Sala, Xavier
• dc.contributor.author Gómez-Gracia, Enrique
• dc.contributor.author Muñoz-Bravo, Carlos
• dc.date.accessioned 2023-04-14T06:21:24Z
• dc.date.available 2023-04-14T06:21:24Z
• dc.date.issued 2022
• dc.description.abstract Background: Selenium is an essential trace mineral with potential interest for cardiovascular disease (CVD) prevention owing to its antioxidant properties. Epidemiological data on selenium status and CVD remain inconsistent. The objective of this study was to ascertain whether low serum selenium (SSe) concentrations are related to an increased risk of a first CVD event in a population at high cardiovascular risk. Methods: We undertook a case-control study nested within the “PREvención con DIeta MEDiterránea” (PREDIMED) trial. A total of 207 participants diagnosed with CVD (myocardial infarction, stroke, or cardiovascular death) during the follow-up period (2003−2010) were matched by sex, age, and intervention group to 436 controls by incidence density sampling. Median time between serum sample collection and subsequent CVD event occurrence was 0.94 years. SSe levels were determined using inductively coupled plasma mass spectrometry analysis. Covariates were assessed through validated questionnaires, in-person interviews, and medical record reviews. Conditional logistic regression was used to calculate multivariable-adjusted odds ratios (ORs). Results: Among women, the mean SSe concentration was lower in cases than in controls (98.5 μg/L vs. 103.8 μg/L; p = 0.016). In controls, SSe levels were directly associated with percentage of total energy intake from proteins and fish intake (p for linear trend < 0.001 and 0.049, respectively), whereas SSe concentrations were inversely associated with age, body mass index, and percentage of total energy intake from carbohydrates (p for linear trend < 0.001, 0.008 and 0.016 respectively). In the total group, we observed an inverse dose−response gradient between SSe levels and risk of CVD in the fully-adjusted model (highest vs. lowest quartile: OR = 0.47, 95% CI: 0.27−0.81; ptrend = 0.003). Conclusions: Among elderly individuals at high cardiovascular risk, high SSe concentrations within population reference values are associated with lower first CVD incidence.
• dc.description.sponsorship This research was funded by the official funding agency for biomedical research of the Spanish government, Instituto de Salud Carlos III (ISCIII), through grants provided to research networks specifically developed for the trial (RTIC G03/140; RTIC RD 06/0045 “PREDIMED”), and JR14/00008, and through Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn), and by grants from Centro Nacional de Investigaciones Cardiovasculares (CNIC 06/2007), the Fondo de Investigación Sanitaria–Fondo Europeo de Desarrollo Regional (Proyecto de Investigación (PI04-2239, PI05/2584, CP06/00100, PI07/0240, PI07/1138, PI07/0954, PI 07/0473, PI10/01407, PI10/02658, PI11/01647, P11/02505 and PI13/00462), the Ministerio de Ciencia e Innovación (Recursos y teconologia agroalimentarias (AGL)-2009-13906-C02 and AGL2010-22319-C03 and AGL2013-49083C3-1-R), the Ministerio de Economía y Competitividad-Fondos FEDER-Instituto de Salud Carlos III (UNGR15-CE-3380), the Fundación Mapfre 2010, the Consejería de Salud de la Junta de Andalucía (PI0105/2007), the Public Health Division of the Department of Health of the Autonomous Government of Catalonia, the Generalitat Valenciana Ayuda Complementatia GVACOMP 06109, GVACOMP2010-181, GVACOMP2011-151, PROMETEO 21/2021, Conselleria de Sanitat y Atención Primaria CS2010-AP-111, and CS2011-AP-042, Regional Government of Navarra (P27/2011), and Centre Català de la Nutrició de l’Institut d’Estudis Catalans. Hojiblanca and Patrimonio Communal Olivarero donated extra-virgin olive oil; the California Walnut Commission donated walnuts; Borges donated almonds; La Morella Nuts donated hazelnuts.
• dc.format.mimetype application/pdf
• dc.identifier.citation Gutiérrez-Bedmar M, Gil F, Olmedo P, Ruiz-Canela M, Martínez-González MÁ, Salas-Salvadó J, Babio N, Fitó M, Del Val García JL, Corella D, Sorlí JV, Ros E, Fiol M, Estruch R, Santos-Lozano JM, Arós F, Serra-Majem L, Pintó X, Gómez-Gracia E, Muñoz-Bravo C. Serum selenium and incident cardiovascular disease in the PREvención con DIeta MEDiterránea (PREDIMED) trial: Nested case-control study. J Clin Med. 2022 Nov 10;11(22):6664. DOI: 10.3390/jcm11226664
• dc.identifier.doi http://dx.doi.org/10.3390/jcm11226664
• dc.identifier.issn 2077-0383
• dc.identifier.uri http://hdl.handle.net/10230/56464
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof J Clin Med. 2022 Nov 10;11(22):6664
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/AGL2009-13906-C02
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/AGL2010-22319-C03
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/AGL2013-49083C3-1-R
• dc.rights © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword PREDIMED
• dc.subject.keyword Cardiovascular disease
• dc.subject.keyword Mediterranean diet
• dc.subject.keyword Older populations
• dc.subject.keyword Serum selenium
• dc.title Serum selenium and incident cardiovascular disease in the PREvención con DIeta MEDiterránea (PREDIMED) trial: Nested case-control study
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion