Childhood exposure to non-persistent endocrine disruptors, glucocorticosteroids, and attentional function: A cross-sectional study based on the parametric g-formula
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- dc.contributor.author Fabbri, Lorenzo
- dc.contributor.author Robinson, Oliver
- dc.contributor.author Basagaña Flores, Xavier
- dc.contributor.author Gražulevičienė, Regina
- dc.contributor.author Guxens Junyent, Mònica
- dc.contributor.author Kadawathagedara, Manik
- dc.contributor.author Sakhi, Amrit Kaur
- dc.contributor.author Maitre, Léa
- dc.contributor.author McEachan, Rosemary R.C.
- dc.contributor.author Philippat, Claire
- dc.contributor.author Pozo Mendoza, Óscar J., 1975-
- dc.contributor.author Thomsen, Cathrine
- dc.contributor.author Wright, John
- dc.contributor.author Yang, Tiffany C.
- dc.contributor.author Vrijheid, Martine
- dc.date.accessioned 2025-01-16T12:27:47Z
- dc.date.available 2025-01-16T12:27:47Z
- dc.date.issued 2025
- dc.description.abstract Background: Evidence suggests that endocrine disrupting chemicals (EDCs) may perturb the hypothalamic-pituitary-adrenocortical (HPA) axis, which has a major role in brain development. We aimed to evaluate the effects of childhood exposure to organophosphate pesticides, phenols, and phthalate metabolites, on urinary glucocorticosteroids and inattention in childhood. Methods: We used data from the Human Early-Life Exposome (HELIX) cohort (2013-2016) and the parametric g-formula to estimate associations between EDCs, glucocorticosteroids, and hit reaction time standard error (HRT-SE), a measure of inattention, and tested for possible effect modification by sex. Results: We observed a positive marginal contrast (MC) for exposure increases from the 10th to the 90th percentile for methyl-paraben (MC: 0.042 and 95% confidence interval (CI): (0.013, 0.071)), and the phthalate metabolites oxo-MiNP (MC: 0.023 and 95% CI: (0.003, 0.044)), oh-MiNP (MC: 0.039 and 95% CI: (0.001, 0.076)), and MEHP (MC: 0.036 and 95% CI: (0.008, 0.063)), on HRT-SE, indicating lower attention. Several EDCs were also associated with a positive MC for cortisone, cortisol, and corticosterone production. Increased levels of the glucocorticosteroids were not associated with HRT-SE, although we found a possible effect modification by sex. Conclusions: Our results suggest that multiple EDCs might interfere with inattention and with the homeostasis of the HPA axis.
- dc.format.mimetype application/pdf
- dc.identifier.citation Fabbri L, Robinson O, Basagaña X, Chatzi L, Gražulevičienė R, Guxens M, et al. Childhood exposure to non-persistent endocrine disruptors, glucocorticosteroids, and attentional function: A cross-sectional study based on the parametric g-formula. Environ Res. 2025 Jan 1;264(Pt 2):120413. DOI: 10.1016/j.envres.2024.120413
- dc.identifier.doi http://dx.doi.org/10.1016/j.envres.2024.120413
- dc.identifier.issn 0013-9351
- dc.identifier.uri http://hdl.handle.net/10230/69159
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Environ Res. 2025 Jan 1;264(Pt 2):120413
- dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/825712
- dc.rights © 2024 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
- dc.subject.keyword Causality
- dc.subject.keyword Cortisone
- dc.subject.keyword Endocrine disruptors
- dc.subject.keyword Hydrocortisone
- dc.subject.keyword Neuropsychological tests
- dc.title Childhood exposure to non-persistent endocrine disruptors, glucocorticosteroids, and attentional function: A cross-sectional study based on the parametric g-formula
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion