Single neuron responses underlying face recognition in the human midfusiform face-selective cortex

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• dc.contributor.author Quian Quiroga, Rodrigo
• dc.contributor.author Boscaglia, Marta
• dc.contributor.author Jonas, Jacques
• dc.contributor.author Rey, Hernan G.
• dc.contributor.author Yan, Xiaoqian
• dc.contributor.author Maillard, Louis
• dc.contributor.author Colnat-Coulbois, Sophie
• dc.contributor.author Koessler, Laurent
• dc.contributor.author Rossion, Bruno
• dc.date.accessioned 2024-05-28T06:23:11Z
• dc.date.available 2024-05-28T06:23:11Z
• dc.date.issued 2023
• dc.description.abstract Faces are critical for social interactions and their recognition constitutes one of the most important and challenging functions of the human brain. While neurons responding selectively to faces have been recorded for decades in the monkey brain, face-selective neural activations have been reported with neuroimaging primarily in the human midfusiform gyrus. Yet, the cellular mechanisms producing selective responses to faces in this hominoid neuroanatomical structure remain unknown. Here we report single neuron recordings performed in 5 human subjects (1 male, 4 females) implanted with intracerebral microelectrodes in the face-selective midfusiform gyrus, while they viewed pictures of familiar and unknown faces and places. We observed similar responses to faces and places at the single cell level, but a significantly higher number of neurons responding to faces, thus offering a mechanistic account for the face-selective activations observed in this region. Although individual neurons did not respond preferentially to familiar faces, a population level analysis could consistently determine whether or not the faces (but not the places) were familiar, only about 50 ms after the initial recognition of the stimuli as faces. These results provide insights into the neural mechanisms of face processing in the human brain.
• dc.format.mimetype application/pdf
• dc.identifier.citation Quian Quiroga R, Boscaglia M, Jonas J, Rey HG, Yan X, Maillard L, et al. Single neuron responses underlying face recognition in the human midfusiform face-selective cortex. Nat Commun. 2023 Sep 13;14(1):5661. DOI: 10.1038/s41467-023-41323-5
• dc.identifier.doi http://dx.doi.org/10.1038/s41467-023-41323-5
• dc.identifier.issn 2041-1723
• dc.identifier.uri http://hdl.handle.net/10230/60262
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Nat Commun. 2023 Sep 13;14(1):5661
• dc.rights © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Extrastriate cortex
• dc.subject.keyword Sensory processing
• dc.title Single neuron responses underlying face recognition in the human midfusiform face-selective cortex
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion