Brain-muscle communication prevents muscle aging by maintaining daily physiology

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• dc.contributor.author Kumar, Arun
• dc.contributor.author Vaca Dempere, Mireia, 1994-
• dc.contributor.author Mortimer, Thomas
• dc.contributor.author Deryagin, Oleg
• dc.contributor.author Smith, Jacob G.
• dc.contributor.author Petrus, Paul
• dc.contributor.author Koronowski, Kevin B.
• dc.contributor.author Greco, Carolina M.
• dc.contributor.author Segalés Dalmau, Jessica
• dc.contributor.author Andrés, Eva
• dc.contributor.author Lukesova, Vera
• dc.contributor.author Zinna, Valentina M.
• dc.contributor.author Welz, Patrick-Simon
• dc.contributor.author Serrano Sánchez, Antonio L.
• dc.contributor.author Perdiguero, Eusebio, 1968-
• dc.contributor.author Sassone-Corsi, Paolo
• dc.contributor.author Aznar Benitah, Salvador
• dc.contributor.author Muñoz Cánoves, Pura, 1962-
• dc.date.accessioned 2024-11-13T07:07:03Z
• dc.date.available 2024-11-13T07:07:03Z
• dc.date.issued 2024
• dc.description.abstract A molecular clock network is crucial for daily physiology and maintaining organismal health. We examined the interactions and importance of intratissue clock networks in muscle tissue maintenance. In arrhythmic mice showing premature aging, we created a basic clock module involving a central and a peripheral (muscle) clock. Reconstituting the brain-muscle clock network is sufficient to preserve fundamental daily homeostatic functions and prevent premature muscle aging. However, achieving whole muscle physiology requires contributions from other peripheral clocks. Mechanistically, the muscle peripheral clock acts as a gatekeeper, selectively suppressing detrimental signals from the central clock while integrating important muscle homeostatic functions. Our research reveals the interplay between the central and peripheral clocks in daily muscle function and underscores the impact of eating patterns on these interactions.
• dc.description.sponsorship The authors acknowledge funding from MICINN-Spain (RTI2018-096068 to P.M.-C. and E.P.), ERC-2016-AdG-741966 to P.M.-C., María-de-Maeztu Program for Units of Excellence to UPF (MDM-2014-0370), and Altos Labs Inc. Research in the S.A.B. laboratory is supported by ERC-787041, the Foundation Lilliane Bettencourt, the Spanish Association for Cancer Research (AECC), and the Worldwide Cancer Research Foundation (WCRF). The IRB Barcelona is a Severo Ochoa Center of Excellence (SEV-2015-0505). K.B.K. acknowledges funding from NIH F32 Fellowship DK121425. P.P. was funded by The Wenner-Gren Foundations and the Foundation Blanceflor Boncompagni Ludovisi, née Bildt. C.M.G. acknowledges funding from European Union’s Horizon 2020 Research and Innovation Programme under the Marie Sklodowska-Curie grant agreement 749869. P.P. was funded by the Wenner-Gren Foundations and the Foundation Blanceflor Boncompagni Ludovisi, née Bildt. V.M.Z. received financial support through the “la Caixa” INPhINIT fellowship grant for doctoral studies at Spanish Research Centers of Excellence, “la Caixa” Foundation, Barcelona (ID 100010434) with fellowship code (LCF/BQ/IN17/11620018). P.-S.W. is supported by grant RYC2019-026661-I funded by MCIN/AEI/10.13039/501100011033 and by “ESF Investing in your future.”
• dc.format.mimetype application/pdf
• dc.identifier.citation Kumar A, Vaca-Dempere M, Mortimer T, Deryagin O, Smith JG, Petrus P, et al. Brain-muscle communication prevents muscle aging by maintaining daily physiology. Science. 2024 May 3;384(6695):563-72. DOI: 10.1126/science.adj8533
• dc.identifier.doi http://dx.doi.org/10.1126/science.adj8533
• dc.identifier.issn 0036-8075
• dc.identifier.uri http://hdl.handle.net/10230/68504
• dc.language.iso eng
• dc.publisher American Association for the Advancement of Science (AAAS)
• dc.relation.ispartof Science. 2024 May 3;384(6695):563-72
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/741966
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/RTI2018-096068
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/787041
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/749869
• dc.rights This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science on 2024;384(6695), DOI: 10.1126/science.adj8533
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.other Envelliment
• dc.subject.other Músculs
• dc.title Brain-muscle communication prevents muscle aging by maintaining daily physiology
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion