Pigmentation phototype and prostate and breast cancer in a select Spanish population-A Mendelian randomization analysis in the MCC-Spain study
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- dc.contributor.author Gómez-Acebo, Inés
- dc.contributor.author Castaño Vinyals, Gemma
- dc.contributor.author Kogevinas, Manolis
- dc.contributor.author Llorca, Javier
- dc.date.accessioned 2019-07-09T07:28:19Z
- dc.date.available 2019-07-09T07:28:19Z
- dc.date.issued 2018
- dc.description.abstract INTRODUCTION: Phototype has been associated with an increased risk of prostate cancer, and it is yet unknown if it is related to other hormone-dependent cancers, such as breast cancer or whether this association could be considered causal. METHODS: We examined the association between the phototype and breast and prostate cancers using a Mendelian randomization analysis. We studied 1,738 incident cases of breast cancer and another 817 cases of prostate cancer. To perform a Mendelian randomization analysis on the phototype-cancer relationship, a genetic pigmentation score was required that met the following criteria: (1) the genetic pigmentation score was associated with phototype in controls; (2) the genetic pigmentation score was not associated with confounders in the relationship between phototype and cancer, and (3) the genetic pigmentation score was associated with cancer only through its association with phototype. Once this genetic score is available, the association between genetic pigmentation score and cancer can be identified as the association between phototype and cancer. RESULTS: The association between the genetic pigmentation score and phototype in controls showed that a higher genetic pigmentation score was associated with fair skin, blond hair, blue eyes and the presence of freckles. Applying the Mendelian randomization analysis, we verified that there was no association between the genetic pigmentation score and cancers of the breast and prostate. CONCLUSIONS: Phototype is not associated with breast or prostate cancer.
- dc.format.mimetype application/pdf
- dc.identifier.citation Gómez-Acebo I, Dierssen-Sotos T, Palazuelos C, Fernández-Navarro P, Castaño-Vinyals G, Alonso-Molero J et al. Pigmentation phototype and prostate and breast cancer in a select Spanish population-A Mendelian randomization analysis in the MCC-Spain study. PLoS One. 2018 Aug 14;13(8):e0201750. DOI: 10.1371/journal.pone.0201750
- dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0201750
- dc.identifier.issn 1932-6203
- dc.identifier.uri http://hdl.handle.net/10230/41959
- dc.language.iso eng
- dc.publisher Public Library of Science (PLoS)
- dc.relation.ispartof PLoS One. 2018 Aug 14;13(8):e0201750
- dc.rights Copyright © 2018 Gómez-Acebo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri https://creativecommons.org/licenses/by/4.0/
- dc.subject.other Hormones
- dc.subject.other Pròstata -- Càncer -- Aspectes genètics
- dc.subject.other Mama -- Càncer -- Aspectes genètics
- dc.title Pigmentation phototype and prostate and breast cancer in a select Spanish population-A Mendelian randomization analysis in the MCC-Spain study
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion