Changes in plasma total saturated fatty acids and palmitic acid are related to pro-inflammatory molecule IL-6 concentrations after nutritional intervention for one year

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Domínguez-López, Inés
• dc.contributor.author Arancibia-Riveros, Camila
• dc.contributor.author Casas, Rosa
• dc.contributor.author Tresserra-Rimbau, Anna
• dc.contributor.author Razquin, Cristina
• dc.contributor.author Martínez-González, Miguel Ángel, 1957-
• dc.contributor.author Hu, Frank B.
• dc.contributor.author Ros, Emilio
• dc.contributor.author Fitó Colomer, Montserrat
• dc.contributor.author Estruch, Ramón
• dc.contributor.author López-Sabater, M. Carmen
• dc.date.accessioned 2022-10-07T06:28:10Z
• dc.date.available 2022-10-07T06:28:10Z
• dc.date.issued 2022
• dc.description.abstract Systemic inflammation is associated with an increased risk of non-communicable diseases, such as cardiovascular diseases and diabetes. Circulating fatty acids (FA) are known to be related to these conditions, possibly through their role in inflammation, although different types of FAs can have opposite effects on inflammatory mediators. The aim of the present study was to analyze the association of plasma FAs with inflammatory biomarkers in a PREDIMED trial subsample after one year of intervention. In a one-year longitudinal study of 91 participants of the PREDIMED trial (Barcelona-Clinic center), plasma FAs and inflammatory biomarkers were analyzed using gas chromatography and ELISA, respectively. In baseline plasma, a multivariable-adjusted ordinary least squares regression model showed that n-3 polyunsaturated FAs concentrations were inversely associated with concentrations of soluble intercellular adhesion molecule-1 (sICAM-1) and E-selectin, whereas the level of the most abundant saturated FA, palmitic acid, was directly associated with concentrations of interleukin-6 (IL-6) (β = 0.48 pg/mL, 95% CI: 0.03, 0.93 per 1-SD increase, p-value = 0.037). After one year of nutritional intervention, changes of plasma diet-derived total saturated FAs and palmitic acid were directly associated with changes in IL-6 (β = 0.59 pg/mL [95% CI: 0.28, 0.89] per 1-SD, p-value = 0.001; β = 0.64 pg/mL, 95% CI: 0.31, 0.98, p-value = 0.001), respectively, after correction for multiple testing. Our findings suggest that saturated FAs of dietary origin, especially palmitic acid, are directly involved in the increase of IL-6 in plasma.
• dc.format.mimetype application/pdf
• dc.identifier.citation Domínguez-López I, Arancibia-Riveros C, Casas R, Tresserra-Rimbau A, Razquin C, Martínez-González MÁ, et al. Changes in plasma total saturated fatty acids and palmitic acid are related to pro-inflammatory molecule IL-6 concentrations after nutritional intervention for one year. Biomed Pharmacother. 2022 Jun; 150: 113028. DOI: 10.1016/j.biopha.2022.113028
• dc.identifier.doi http://dx.doi.org/10.1016/j.biopha.2022.113028
• dc.identifier.issn 0753-3322
• dc.identifier.uri http://hdl.handle.net/10230/54310
• dc.language.iso eng
• dc.publisher Elsevier
• dc.rights 0753-3322/© 2022, Domínguez-López I, Arancibia-Riveros C, Casas R, Tresserra-Rimbau A, Razquin C, Martínez-González MÁ. Published by Elsevier Masson SAS. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Fatty acids
• dc.subject.keyword Inflammation
• dc.subject.keyword Longitudinal study
• dc.subject.keyword Mediterranean diet
• dc.subject.keyword PREDIMED
• dc.subject.keyword Palmitic acid
• dc.title Changes in plasma total saturated fatty acids and palmitic acid are related to pro-inflammatory molecule IL-6 concentrations after nutritional intervention for one year
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion