Is there adaptation in the human genome for taste perception and phase I biotransformation?

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• dc.contributor.author Dobón Berenguer, Begoña, 1987-
• dc.contributor.author Rossell, Carla
• dc.contributor.author Walsh Capdevila, Sandra, 1991-
• dc.contributor.author Bertranpetit, Jaume, 1952-
• dc.date.accessioned 2019-03-19T08:33:17Z
• dc.date.available 2019-03-19T08:33:17Z
• dc.date.issued 2019
• dc.description.abstract Background: During the modern human expansion, new environmental pressures may have driven adaptation, especially in genes related to the perception of ingested substances and their detoxification. Consequently, positive (adaptive) selection may have occurred in genes related to taste, and in those related to the CYP450 system due to its role in biotransformation of potentially toxic compounds. A total of 91 genes (taste receptors and CYP450 superfamily) have been studied using Hierarchical Boosting, a powerful combination of different selection tests, to detect signatures of recent positive selection in three continental human populations: Northern Europeans (CEU), East Asians (CHB) and Africans (YRI). Analyses have been refined with selection analyses of the 26 populations of 1000 Genomes Project Phase 3. Results: Genes related to taste perception have not been positively selected in the three continental human populations. This finding suggests that, contrary to results of previous studies, different allele frequencies among populations in genes such as TAS2R38 and TAS2R16 are not due to positive selection but to genetic drift. CYP1 and CYP2 genes, also previously considered to be under positive selection, did not show signatures of selective sweeps. However, three genes belonging to the CYP450 system have been identified by the Hierarchical Boosting as positively selected: CYP3A4 and CYP3A43 in CEU, and CYP27A1 in CHB. Conclusions: No main adaptive differences are found in known taste receptor genes among the three continental human populations studied. However, there are important genetic adaptations in the cytochrome P450 system related to the Out of Africa expansion of modern humans. We confirmed that CYP3A4 and CYP3A43 are under selection in CEU, and we report for the first time CYP27A1 to be under positive selection in CHB.
• dc.description.sponsorship This study has been possible thanks to grant BFU2016–77961-P (AEI/FEDER, UE) awarded by the Agencia Estatal de Investigación (Ministerio de Ciencia, Innovación y Universidades, Spain) and with the support of Secretaria d’Universitats i Recerca del Departament d’Economia i Coneixement de la Generalitat de Catalunya (GRC 2017 SGR 702). Part of the “Unidad de Excelencia María de Maeztu” (MDM-2014-0370), funded by the Ministerio de Economía, Industria y Competividad (MINECO, Spain). BD is supported by F.P.U. grant FPU13/06813 from the Ministerio de Educación, Cultura y Deporte (Spain). SW is supported by F.P.I grant BES-2014-068994 from MINECO.
• dc.format.mimetype application/pdf
• dc.identifier.citation Dobon B, Rossell C, Walsh S, Bertranpetit J. Is there adaptation in the human genome for taste perception and phase I biotransformation? BMC Evol Biol. 2019;19(1):39. DOI 10.1186/s12862-019-1366-7
• dc.identifier.doi http://dx.doi.org/10.1186/s12862-019-1366-7
• dc.identifier.issn 1471-2148
• dc.identifier.uri http://hdl.handle.net/10230/36864
• dc.language.iso eng
• dc.publisher BioMed Central
• dc.relation.ispartof BMC Evolutionary Biology. 2019;19(1):39
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2016–77961-P
• dc.rights © The Author(s). 2019 Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Taste perception
• dc.subject.keyword Taste perception
• dc.subject.keyword Cytochrome P450
• dc.subject.keyword Natural selection
• dc.subject.keyword CYP3A4
• dc.subject.keyword CYP3A43
• dc.subject.keyword CYP27A1
• dc.title Is there adaptation in the human genome for taste perception and phase I biotransformation?
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion