Impact of gender on the willingness to participate in clinical trials and undergo related procedures in individuals from an Alzheimer's prevention research cohort

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• dc.contributor.author Canals-Gispert, Lidia
• dc.contributor.author Cañas-Martínez, Alba
• dc.contributor.author Huesa, Gema
• dc.contributor.author Suárez-Calvet, Marc
• dc.contributor.author Milà Alomà, Marta
• dc.contributor.author Arenaza Urquijo, Eider M.
• dc.contributor.author Cirillo, Davide
• dc.contributor.author Schumacher Dimech, Annemarie
• dc.contributor.author Iulita, Maria Florencia
• dc.contributor.author Novakova Martinkova, Julie
• dc.contributor.author Tartaglia, Maria Carmela
• dc.contributor.author Quevenco, Frances-Catherine
• dc.contributor.author Santuccione Chadha, Antonella
• dc.contributor.author Sánchez Benavides, Gonzalo
• dc.contributor.author Minguillón, Carolina
• dc.contributor.author Ferretti, Maria Teresa
• dc.contributor.author Fauria, Karine
• dc.contributor.author Brugulat Serrat, Anna, 1986-
• dc.contributor.author ALFA Study
• dc.date.accessioned 2025-10-03T06:21:18Z
• dc.date.available 2025-10-03T06:21:18Z
• dc.date.issued 2024
• dc.description.abstract Background: Although there is growing evidence of the association between gender and early diagnosis of preclinical Alzheimer's disease, little attention has been given to the enrolment ratio of men and women in clinical trials and data reporting. Methods: This study aims to analyze gender differences in sociodemographic factors associated with the willingness to participate in clinical trials and undergo specific procedures in the context of an Alzheimer's disease prevention research cohort. 2544 cognitively unimpaired participants from the ALFA parent cohort (age 45-75 years) of the Barcelonaβeta Brain Research Center were contacted through a structured phone call to determine their willingness to participate in Alzheimer's disease clinical trials and undergo trial-related procedures (magnetic resonance imaging, lumbar puncture, positron emission tomography, and cognitive assessment). Sociodemographic data on education, occupational attainment, civil and caregiver status were gathered. Stepwise logistic regression models were performed in order to study the interaction between gender and sociodemographic factors in the willingness to participate in clinical trials and to undergo clinical trial-related procedures. Results: 1,606 out of the 2,544 participants were women (63.1%). Women were significantly younger and had lower educational attainment compared with men. In addition, women were more likely to be caregivers, single and unemployed. Women showed a significantly lower willingness than men to participate in a clinical trial (p = 0.003) and to undergo a lumbar puncture (p < 0.001). Single women were less willing to participate in clinical trials than single men (p = 0.041). Regarding clinical trial-related procedures, women with higher years of education were significantly less willing to undergo a lumbar puncture (p = 0.031). Conclusion: We found gender differences regarding the sociodemographic factors that predict the willingness to participate in clinical trials and to undergo clinical trial-related procedures. Our results highlight the urgent need to design recruitment strategies accounting for gender-related factors, particularly those related to marital status and education.
• dc.description.sponsorship The project leading to these results has received funding from “la Caixa” Foundation (ID 100010434), under agreement LCF/PR/GN17/10300004. JNM is supported by project nr. LX22NPO5107 (MEYS): Financed by EU – Next Generation EU. MSC receives funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (Grant agreement No. 948677), the Instituto de Salud Carlos III through the projects PI19/00155 and PI22/00456 (Co-funded by European Regional Development Fund (FEDER) "A way to make Europe"), and receives the support of a fellowship from”la Caixa” Foundation (ID 100010434) and from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 847648 (fellowship code LCF/BQ/PR21/11840004). EMAU receives funding from the Alzheimer’s Association (AARG 2019-AARG-644641, AARG 2019-AARG-644641-RAPID), and from the Ministry of Science and Innovation (MCIN)/Spanish Research Agency (AEI) MCIN/AEI/https://doi.org/10.13039/501100011033 (PID2019-111514RA-I00 and RYC2018-026053-I, co-funded by the European Social Fund (FSE)). GSB receives funding from the Ministry of Science and Innovation/Spanish Research Agency (PID2020-119556RA-I00 funded by MCIN/AEI/https://doi.org/10.13039/501100011033/FEDER, UE). ABS receives funding from the Global Brain Health Institute (GBHI), Alzheimer's Association, Alzheimer's Society (GBHI ALZ UK-21–737797).
• dc.format.mimetype application/pdf
• dc.identifier.citation Canals-Gispert L, Cañas-Martínez A, Huesa G, Suárez-Calvet Alomà M, Milà-Alomà M, Arenaza-Urquijo E, et al. Impact of gender on the willingness to participate in clinical trials and undergo related procedures in individuals from an Alzheimer's prevention research cohort. Alzheimers Res Ther. 2024 Dec 19;16(1):263. DOI: 10.1186/s13195-024-01626-1
• dc.identifier.doi http://dx.doi.org/10.1186/s13195-024-01626-1
• dc.identifier.issn 1758-9193
• dc.identifier.uri http://hdl.handle.net/10230/71353
• dc.language.iso eng
• dc.publisher BioMed Central
• dc.relation.ispartof Alzheimers Res Ther. 2024 Dec 19;16(1):263
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/948677
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/847648
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-111514RA-I00
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2020-119556RA-I00
• dc.rights © The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Alzheimer’s disease
• dc.subject.keyword Clinical trials
• dc.subject.keyword Gender
• dc.subject.keyword Lumbar puncture
• dc.subject.keyword Precision medicine
• dc.title Impact of gender on the willingness to participate in clinical trials and undergo related procedures in individuals from an Alzheimer's prevention research cohort
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion