Brain-derived neurotrophic factor levels in first episode of psychosis: A systematic review.
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- dc.contributor.author Toll Privat, Albaca
- dc.contributor.author Mané Santacana, Annaca
- dc.date.accessioned 2015-06-09T10:43:49Z
- dc.date.available 2015-06-09T10:43:49Z
- dc.date.issued 2015
- dc.description.abstract AIM: To systematically review studies measuring peripheric brain-derived neurotrophic factor (BDNF) levels on first-episode psychosis patients and variables related to them. METHODS: A systematic search was made of articles published in the Medline database from 2002 up to June 2014. Included are original studies that report enzyme-linked immunosorbent assay measurement of BDNF levels in serum or plasma in patients with a diagnosis of first episode psychosis (FEP) and age- and gender- matched healthy controls. RESULTS: Of the initially identified 147 articles, only 18 satisfied the inclusion criteria. Of this, 15 found a significant reduction in patients with FEP compared with age- and gender - matched controls. CONCLUSION: Peripheral BDNF levels are generally reduced in FEP patients. There are some factors that may influence BDNF levels that need to be further studied. Furthermore, a future meta-analysis in this topic is needed.ca
- dc.format.mimetype application/pdfca
- dc.identifier.citation Toll A, Mané A. Brain-derived neurotrophic factor levels in first episode of psychosis: A systematic review. World J Psychiatry. 2015 Mar 22;5(1):154-9. doi: 10.5498/wjp.v5.i1.154.ca
- dc.identifier.doi http://dx.doi.org/10.5498/wjp.v5.i1.154
- dc.identifier.issn 2220-3206
- dc.identifier.uri http://hdl.handle.net/10230/23778
- dc.language.iso engca
- dc.publisher Baishideng Publishing Groupca
- dc.relation.ispartof World Journal of Psychiatry. 2015 Mar 22;5(1):154-9
- dc.rights This article is an open-access article which was/nselected by an in-house editor and fully peer-reviewed by external/nreviewers. It is distributed in accordance with the Creative/nCommons Attribution Non Commercial (CC BY-NC 4.0) license,/nwhich permits others to distribute, remix, adapt, build upon this/nwork non-commercially, and license their derivative works on/ndifferent terms, provided the original work is properly cited and/nthe use is non-commercial. See: http://creativecommons.org//nlicenses/by-nc/4.0/ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
- dc.subject.other Psicosica
- dc.subject.other Cervell -- Fisiologiaca
- dc.title Brain-derived neurotrophic factor levels in first episode of psychosis: A systematic review.ca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca