Polycomb complexes in normal and malignant hematopoiesis

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  • dc.contributor.author Di Carlo, Valerio
  • dc.contributor.author Mocavini, Ivano
  • dc.contributor.author Di Croce, Luciano
  • dc.date.accessioned 2019-05-20T07:54:50Z
  • dc.date.available 2019-05-20T07:54:50Z
  • dc.date.issued 2019
  • dc.description.abstract Epigenetic mechanisms are crucial for sustaining cell type-specific transcription programs. Among the distinct factors, Polycomb group (PcG) proteins are major negative regulators of gene expression in mammals. These proteins play key roles in regulating the proliferation, self-renewal, and differentiation of stem cells. During hematopoietic differentiation, many PcG proteins are fundamental for proper lineage commitment, as highlighted by the fact that a lack of distinct PcG proteins results in embryonic lethality accompanied by differentiation biases. Correspondingly, proteins of these complexes are frequently dysregulated in hematological diseases. In this review, we present an overview of the role of PcG proteins in normal and malignant hematopoiesis, focusing on the compositional complexity of PcG complexes, and we briefly discuss the ongoing clinical trials for drugs targeting these factors.
  • dc.description.sponsorship Support to the Di Croce laboratory comes from grants from the Spanish Ministry of Economy, Industry, and Competitiveness (BFU2016-75008-P), the European Regional Development Fund (FEDER), Fundacion Vencer El Cancer, and Agència de Gestió d’Ajuts Universitaris i de Recerca; to V. Di Carlo from an ImPuLSe Marie Curie Postdoctoral Fellowship of the European Union Seventh Framework Program (FP7/2007-2013; grant 608959); and I. Mocavini from an FPI fellowship. We acknowledge support of the Spanish Ministry of Economy, Industry, and Competitiveness through the Instituto de Salud Carlos III and for the European Molecular Biology Laboratory partnership; Centro de Excelencia Severo Ochoa; and the Centres de Recerca de Catalunya Program/Generalitat de Catalunya.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Di Carlo V, Mocavini I, Di Croce L. Polycomb complexes in normal and malignant hematopoiesis. J Cell Biol. 2019; 218(1):55-69. DOI 10.1083/jcb.201808028
  • dc.identifier.doi http://dx.doi.org/10.1083/jcb.201808028
  • dc.identifier.issn 0021-9525
  • dc.identifier.uri http://hdl.handle.net/10230/37246
  • dc.language.iso eng
  • dc.publisher Rockefeller University Press
  • dc.relation.ispartof J Cell Biol. 2019; 218(1):55-69
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2016-75008-P
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/FP7/608959
  • dc.rights © Di Carlo et al., 2018. Originally published in The Journal of cell biology. doi: 10.1083/jcb.201808028. After 6 months: Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.title Polycomb complexes in normal and malignant hematopoiesis
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/acceptedVersion

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