TWIST1 is expressed in colorectal carcinomas and predicts patient survival
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Gómez, Ireneca
- dc.contributor.author Peña, Cristinaca
- dc.contributor.author Herrera, Mercedesca
- dc.contributor.author Muñoz, Concepciónca
- dc.contributor.author Larriba, María Jesúsca
- dc.contributor.author García, Vanesaca
- dc.contributor.author Domínguez, Gemmaca
- dc.contributor.author Silva, Javierca
- dc.contributor.author Rodríguez, Rufoca
- dc.contributor.author García de Herreros, Antonioca
- dc.contributor.author Bonilla, Félixca
- dc.contributor.author García, Jose M.ca
- dc.date.accessioned 2015-04-30T07:11:21Z
- dc.date.available 2015-04-30T07:11:21Z
- dc.date.issued 2011ca
- dc.description.abstract TWIST1 is a transcription factor that belongs to the family of basic helix-loop-helix proteins involved in epithelial-to-mesenchymal transition and invasion processes. The TWIST1 protein possesses oncogenic, drug-resistant, angiogenic and invasive properties, and has been related with several human tumors and other pathologies. Colorectal cancer is one of the tumors in which TWIST1 is over-expressed, but its involvement in the clinical outcome of the disease is still unclear. We tested, by RT-PCR, the expression levels of TWIST1 in normal and tumor paired-sample tissues from a series of 151 colorectal cancer patients, in order to investigate its prognostic value as a tumor marker. TWIST1 expression was restricted to tumor tissues (86.1%) and correlated with lymph node metastasis (LNM). Adjusted analysis showed that the expression levels of TWIST1 correlated with overall survival (OS) and disease-free survival (DFS). Importantly, TWIST1 expression levels predicted OS specifically at stages I and II. Moreover, patients with stage II tumors and high TWIST1 levels showed even shorter survival than patients with stage III tumors. These results suggest that TWIST1 expression levels could be a tumor indicator in stage II patients and help select patients at greater risk of poor prognosis who might benefit from adjuvant chemotherapy.en
- dc.description.sponsorship This study was supported by grants from: Foundation AECC, S-GEN/0266/2006, RD06/0020/0020, SAF2010-20750 and RD06/0020/0040. JMG is supported by ISCIII-CP08/00217. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the man/nuscripten
- dc.format.mimetype application/pdfca
- dc.identifier.citation Gomez I, Pena C, Herrera M, Muñoz C, Larriba MJ, García V et al. TWIST1 is expressed in colorectal carcinomas and predicts patient survival. PLoS ONE. 2011; 6(3): e18023. DOI 10.1371/journal.pone.0018023ca
- dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0018023
- dc.identifier.issn 1932-6203ca
- dc.identifier.uri http://hdl.handle.net/10230/23499
- dc.language.iso engca
- dc.publisher Public Library of Science (PLoS)ca
- dc.relation.ispartof PLoS ONE. 2011; 6(3): e18023
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2010-20750
- dc.rights © Gomez I, Pena C, Herrera M, Muñoz C, Larriba MJ, García V et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution...(CC BY) (http://creativecommons.org/licenses/by/2.5/).ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri http://creativecommons.org/licenses/by/2.5/
- dc.subject.other Proteïnesca
- dc.subject.other RNA missatgerca
- dc.subject.other Regulació genèticaca
- dc.title TWIST1 is expressed in colorectal carcinomas and predicts patient survivalen
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca