A randomized trial of deep brain stimulation to the subcallosal cingulate and nucleus accumbens in patients with treatment-refractory, chronic, and severe anorexia nervosa: initial results at 6 months of follow up

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• dc.contributor.author Villalba Martínez, Gloria
• dc.contributor.author Justicia Díaz, Azucena
• dc.contributor.author Salgado Serrano, Purificación
• dc.contributor.author Ginés Miranda, José María
• dc.contributor.author Guardiola, Rocío
• dc.contributor.author Cedrón Castro, Carlos
• dc.contributor.author Polo, María
• dc.contributor.author Delgado-Martínez, Ignacio
• dc.contributor.author Medrano-Martorell, Santiago
• dc.contributor.author Manero, Rosa María
• dc.contributor.author Conesa Bertrán, Gerardo
• dc.contributor.author Faus, Gustavo
• dc.contributor.author Grau, Antoni
• dc.contributor.author Elices, Matilde
• dc.contributor.author Pérez Solá, Victor
• dc.date.accessioned 2020-09-30T06:53:44Z
• dc.date.available 2020-09-30T06:53:44Z
• dc.date.issued 2020
• dc.description.abstract Background: The main objective of this study was to assess the safety and efficacy of deep brain stimulation (DBS) in patients with severe anorexia nervosa (AN). Methods: Eight participants received active DBS to the subcallosal cingulate (SCC) or nucleus accumbens (NAcc) depending on comorbidities (affective or anxiety disorders, respectively) and type of AN. The primary outcome measure was body mass index (BMI). Results: Overall, we found no significant difference (p = 0.84) between mean preoperative and postoperative (month 6) BMI. A BMI reference value (BMI-RV) was calculated. In patients that received preoperative inpatient care to raise the BMI, the BMI-RV was defined as the mean BMI value in the 12 months prior to surgery. In patients that did not require inpatient care, the BMI-RV was defined as the mean BMI in the 3-month period before surgery. This value was compared to the postoperative BMI (month 6), revealing a significant increase (p = 0.02). After 6 months of DBS, five participants showed an increase of ≥10% in the BMI-RV. Quality of life was improved (p = 0.03). Three cases presented cutaneous complications. Conclusion: DBS may be effective for some patients with severe AN. Cutaneous complications were observed. Longer term data are needed.
• dc.format.mimetype application/pdf
• dc.identifier.citation Villalba Martínez G, Justicia A, Salgado P, Ginés JM, Guardiola R, Cedrón C. et al. A randomized trial of deep brain stimulation to the subcallosal cingulate and nucleus accumbens in patients with treatment-refractory, chronic, and severe anorexia nervosa: initial results at 6 months of follow up. J Clin Med. 2020 Jun 22; 9(6):1946. DOI: 10.3390/jcm9061946
• dc.identifier.doi http://dx.doi.org/10.3390/jcm9061946
• dc.identifier.issn 2077-0383
• dc.identifier.uri http://hdl.handle.net/10230/45353
• dc.language.iso eng
• dc.publisher MDPI
• dc.rights © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Anorexia nervosa
• dc.subject.keyword Body mass index
• dc.subject.keyword Clinical trial
• dc.subject.keyword Deep brain stimulation
• dc.subject.keyword Nucleus accumbens
• dc.subject.keyword Psychosurgery
• dc.subject.keyword Subcallosal cingulate
• dc.title A randomized trial of deep brain stimulation to the subcallosal cingulate and nucleus accumbens in patients with treatment-refractory, chronic, and severe anorexia nervosa: initial results at 6 months of follow up
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion