North African populations carry the signature of admixture with neandertals
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- dc.contributor.author Sánchez Quinto, Federico A, 1985-ca
- dc.contributor.author Botigué, Laura R.ca
- dc.contributor.author Civit, Sergica
- dc.contributor.author Arenas, Conxitaca
- dc.contributor.author Ávila Arcos, María C.ca
- dc.contributor.author Bustamante, Carlos D.ca
- dc.contributor.author Comas, David, 1969-ca
- dc.contributor.author Lalueza Fox, Carles, 1965-ca
- dc.date.accessioned 2015-05-12T09:47:13Z
- dc.date.available 2015-05-12T09:47:13Z
- dc.date.issued 2012ca
- dc.description.abstract One of the main findings derived from the analysis of the Neandertal genome was the evidence for admixture between Neandertals and non-African modern humans. An alternative scenario is that the ancestral population of non-Africans was closer to Neandertals than to Africans because of ancient population substructure. Thus, the study of North African populations is crucial for testing both hypotheses. We analyzed a total of 780,000 SNPs in 125 individuals representing seven different North African locations and searched for their ancestral/derived state in comparison to different human populations and Neandertals. We found that North African populations have a significant excess of derived alleles shared with Neandertals, when compared to sub-Saharan Africans. This excess is similar to that found in non-African humans, a fact that can be interpreted as a sign of Neandertal admixture. Furthermore, the Neandertal's genetic signal is higher in populations with a local, pre-Neolithic North African ancestry. Therefore, the detected ancient admixture is not due to recent Near Eastern or European migrations. Sub-Saharan populations are the only ones not affected by the admixture event with Neandertals.en
- dc.description.sponsorship FS-Q, SC, CA and CL-F are supported by a grant from the Ministerio de Ciencia e Innovación of Spain (BFU2009-06974) and CGL2010-14944/BOS.en
- dc.format.mimetype application/pdfca
- dc.identifier.citation Sánchez-Quinto F, Botigué LR, Civit S, Arenas C, Avila-Arcos MC, Bustamante CD et al. North African populations carry the signature of admixture with neandertals. PLoS ONE. 2012;7(10):e47765. DOI: 10.1371/journal.pone.0047765ca
- dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0047765
- dc.identifier.issn 1932-6203ca
- dc.identifier.uri http://hdl.handle.net/10230/23560
- dc.language.iso engca
- dc.publisher Public Library of Science (PLoS)ca
- dc.relation.ispartof PLoS ONE. 2012;7(10):e47765
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2009-06974
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/CGL2010-14944
- dc.rights © 2012 Sánchez-Quinto et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are crediteden
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri https://creativecommons.org/licenses/by/4.0/
- dc.subject.other Genètica de poblacions humanes -- Àfrica del Nordca
- dc.subject.other Demografia -- Àfrica del Nord -- Aspectes genèticsca
- dc.title North African populations carry the signature of admixture with neandertalsen
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca