Increase from low to moderate, but not high, caffeinated coffee consumption is associated with favorable changes in body fat

Henn, Mathias; Fitó Colomer, Montserrat; Schröder, Helmut; Ruiz-Canela, Miguel

Increase from low to moderate, but not high, caffeinated coffee consumption is associated with favorable changes in body fat

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dc.contributor.author Henn, Mathias
dc.contributor.author Fitó Colomer, Montserrat
dc.contributor.author Schröder, Helmut
dc.contributor.author Ruiz-Canela, Miguel
dc.date.accessioned 2024-04-12T06:43:28Z
dc.date.available 2024-04-12T06:43:28Z
dc.date.issued 2023
dc.description.abstract Background & aims Higher consumption of coffee and caffeine has been linked to less weight gain and lower body mass index in prospective cohort studies. The aim of the study was to longitudinally assess the association of changes in coffee and caffeine intake with changes in fat tissue, in particular, visceral adipose tissue (VAT) using dual x-ray absorptiometry (DXA). Methods In the setting of a large, randomized trial of Mediterranean diet and physical activity intervention, we evaluated 1483 participants with metabolic syndrome (MetS). Repeated measurements of coffee consumption from validated food frequency questionnaires (FFQ) and DXA measurements of adipose tissue were collected at baseline, 6 months, 12 months and 3 years of follow-up. DXA-derived measurements of total and regional adipose tissue expressed as % of total body weight were transformed into sex-specific z-scores. Linear multilevel mixed-effect models were used to investigate the relationship between changes in coffee consumption and corresponding concurrent changes in fat tissue during a 3-year follow-up. Results After adjustment for intervention group, and other potential confounders, an increase in caffeinated coffee consumption from no or infrequent consumption (≤3 cups/month) to moderate consumption (1–7 cups/week) was associated with reductions in total body fat (Δ z-score: −0.06; 95% CI: −0.11 to −0.02), trunk fat (Δ z-score: −0.07; 95% CI: −0.12 to −0.02), and VAT (Δ z-score: −0.07; 95% CI: −0.13 to −0.01). Neither changes from no or infrequent consumption to high levels of caffeinated coffee consumption (>1 cup/day) nor any changes in decaffeinated coffee consumption showed significant associations with changes in DXA measures. Conclusions Moderate changes in the consumption of caffeinated coffee, but not changes to high consumption, were associated with reductions in total body fat, trunk fat and VAT in a Mediterranean cohort with MetS. Decaffeinated coffee was not linked to adiposity indicators. Moderate consumption of caffeinated coffee may be part of a weight management strategy.
dc.description.sponsorship The PREDIMED-Plus trial was supported by the official funding agency for biomedical research of the Spanish Government, Instituto de Salud Carlos III ([Carlos III Health Institute], Sevilla, Spain), through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/0147, PI14/00636, PI14/00972, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532, PI20/00456, PI20/00339, PI20/00557, PI20/00886, PI20/01158, the European Research Council Advanced Research Grant 2013–2018 340918, the Recercaixa grant 2013ACUP00194, grants from the Consejería de Salud de la Junta de Andalucía PI0458/2013; PS0358/2016, PI0137/2018, the PROMETEO/2017/017 grant from the Generalitat Valenciana, the SEMERGEN grant, FEDER funds CB06/03 and the NIH grant 1R01DK127601-01. Dr. Salas-Salvadó is partially supported by ICREA under the ICREA Academia Program. JK is supported by Juan de la Cierva-Incorporación research grant (IJC2019-042420-I) of the Spanish Ministry of Economy, Industry and Competitiveness and European Social Funds. None of the funding sources took part in the design, collection, analysis or interpretation of the data and in writing the manuscript, or in the decision to submit the manuscript for publication.
dc.format.mimetype application/pdf
dc.identifier.citation Henn M, Babio N, Romaguera D, Vázquez-Ruiz Z, Konieczna J, Vioque J, et al. Increase from low to moderate, but not high, caffeinated coffee consumption is associated with favorable changes in body fat. Clin Nutr. 2023 Apr;42(4):477-85. DOI: 10.1016/j.clnu.2023.02.004
dc.identifier.doi http://dx.doi.org/10.1016/j.clnu.2023.02.004
dc.identifier.issn 0261-5614
dc.identifier.uri http://hdl.handle.net/10230/59745
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Clin Nutr. 2023 Apr;42(4):477-85
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/340918
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/IJC2019-042420-I
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.keyword Coffee consumption
dc.subject.keyword Caffeine
dc.subject.keyword Visceral fat
dc.subject.keyword DXA
dc.subject.keyword PREDIMED-Plus trial
dc.subject.keyword Adiposity distribution
dc.title Increase from low to moderate, but not high, caffeinated coffee consumption is associated with favorable changes in body fat
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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