Increased risk of arrhythmias, heart failure, and thrombosis in SARS-CoV-2 positive individuals persists at one year post-infection

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• dc.contributor.author Tintore, C.
• dc.contributor.author Curtero, Jordi
• dc.contributor.author Camps-Vilaró, Anna
• dc.contributor.author Subirana Cachinero, Isaac
• dc.contributor.author Elosua Llanos, Roberto
• dc.contributor.author Marrugat de la Iglesia, Jaume
• dc.contributor.author Dégano, Irene R.
• dc.date.accessioned 2025-04-16T06:38:38Z
• dc.date.available 2025-04-16T06:38:38Z
• dc.date.issued 2024
• dc.description.abstract Risk of cardiovascular events is increased after COVID-19. However, information on cardiovascular risk trends after COVID-19 infection is lacking and estimates by sex are inconsistent. Our aim was to examine cardiovascular outcomes and mortality in a large cohort (164,346 participants) of SARS-CoV-2 positive individuals compared to non-positive individuals, stratified by sex. Data were obtained from the Spanish Health System's electronic medical records. Selected individuals were ≥ 45 years old with/without a positive SARS-CoV-2 test in the period March-May 2020. Follow-up was obtained until January 31, 2021, for cardiovascular events (angina/myocardial infarction, arrhythmias, bypass/revascularization, heart failure, peripheral artery disease, stroke/transient ischemic attack, and thrombosis), and until March 31, 2021, for mortality. Individuals were matched by propensity score. Incidence of cardiovascular events and mortality was compared with accelerated failure time models. The effect of matching and of COVID-19 severity was assessed with sensitivity analyses. In the first 3 months of follow-up, SARS-CoV-2 positive individuals had a higher risk of mortality and of all cardiovascular events. From 4-12 months, there was increased risk of mortality in SARS-CoV-2 positive individuals overall, of heart failure in SARS-CoV-2 positive females (HR= 1.26 [1.11-1.42]), and of arrhythmias and thrombosis in SARS-CoV-2 positive males (HR= 1.29 [1.14-1.47] and HR= 1.35 [1.03-1.77], respectively). When COVID-19 patients admitted to the ICU were excluded, incidence of thrombosis was similar in males regardless of positive/non-positive SARS-CoV-2 status. In the full year of follow-up, increased incidence of heart failure and of arrhythmias and thrombosis was observed in SARS-CoV-2 positive females and males, respectively.
• dc.format.mimetype application/pdf
• dc.identifier.citation Tintore C, Cuartero J, Camps-Vilaró A, Subirana, Elosua R, Marrugat J, et al. Increased risk of arrhythmias, heart failure, and thrombosis in SARS-CoV-2 positive individuals persists at one year post-infection. Comput Struct Biotechnol J. 2024 Jun 20;24:476-83. DOI: 10.1016/j.csbj.2024.06.024
• dc.identifier.doi http://dx.doi.org/10.1016/j.csbj.2024.06.024
• dc.identifier.issn 2001-0370
• dc.identifier.uri http://hdl.handle.net/10230/70147
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Comput Struct Biotechnol J. 2024 Jun 20;24:476-83
• dc.rights © 2024 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword COVID-19
• dc.subject.keyword Cardiovascular disease
• dc.subject.keyword Mortality
• dc.subject.keyword SARS-CoV-2
• dc.title Increased risk of arrhythmias, heart failure, and thrombosis in SARS-CoV-2 positive individuals persists at one year post-infection
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion