Prenatal concentrations of polychlorinated biphenyls, DDE, and DDT and overweight in children: a prospective birth cohort study

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  • dc.contributor.author Valvi, Damaskini, 1983-ca
  • dc.contributor.author Mendez, Michelle A.ca
  • dc.contributor.author Martínez Muriano, Davidca
  • dc.contributor.author Grimalt Obrador, Joanca
  • dc.contributor.author Torrent Quetglas, Matiesca
  • dc.contributor.author Sunyer Deu, Jordica
  • dc.contributor.author Vrijheid, Martineca
  • dc.date.accessioned 2015-04-09T08:14:34Z
  • dc.date.available 2015-04-09T08:14:34Z
  • dc.date.issued 2012ca
  • dc.description.abstract Background: Recent experimental evidence suggests that prenatal exposure to endocrine-disrupting chemicals (EDCs) may increase postnatal obesity risk and that these effects may be sex or diet dependent. Objectives: We explored whether prenatal organochlorine compound (OC) concentrations [polychlorinated biphenyls (PCBs), dichlorodiphenyldichloroethylene (DDE), and dichlorodiphenyltrichloroethane (DDT)] were associated with overweight at 6.5 years of age and whether child sex or fat intakes modified these associations. Methods: We studied 344 children from a Spanish birth cohort established in 1997–1998. Overweight at 6.5 years was defined as a body mass index (BMI) z-score ≥ 85th percentile of the World Health Organization reference. Cord blood OC concentrations were measured and treated as categorical variables (tertiles). Children’s diet was assessed by food frequency questionnaire. Relative risks (RRs) were estimated using generalized linear models. Results: After multivariable adjustment, we found an increased RR of overweight in the third tertile of PCB exposure [RR = 1.70; 95% confidence interval (CI): 1.09, 2.64] and the second tertile of DDE exposure (RR = 1.67; 95% CI: 1.10, 2.55), but no association with DDT exposure in the population overall. Associations between overweight and PCB and DDE concentrations were strongest in girls (p-interaction between 0.01 and 0.28); DDT was associated with overweight only in boys. For DDT we observed stronger associations in children with fat intakes at or above compared with below the median, but this interaction was not significant (p-interaction > 0.05). Conclusions: This study suggests that prenatal OC exposures may be associated with overweight in children and that sex and high-fat intake may influence susceptibility.en
  • dc.description.sponsorship This study was funded by grants from the Spanish Ministry of Health (FIS-97/0588 and FIS-00/0021-02), the Instituto Carlos III (Red INMA G03176 and predoctoral grant PFIS 2010, Register FI10/00399), the Fundació La Caixa (00/007-00), the RecerCaixa (Register 2010ACUP 00349), and the European Commission (Concerted Action, contract QLK4-2000-00263)en
  • dc.format.mimetype application/pdfca
  • dc.identifier.citation Valvi D, Mendez MA, Martinez D, Grimalt JO, Torrent M, Sunyer J, Vrijheid M. Prenatal concentrations of polychlorinated biphenyls, DDE, and DDT and overweight in children: a prospective birth cohort study. Environ Health Perspect. 2012;120(3):451-7. DOI: 10.1289/ehp.1103862ca
  • dc.identifier.doi http://dx.doi.org/10.1289/ehp.1103862
  • dc.identifier.issn 0091-6765ca
  • dc.identifier.uri http://hdl.handle.net/10230/23367
  • dc.language.iso engca
  • dc.publisher National Institute of Environmental Health Sciences (NIEHS)ca
  • dc.relation.ispartof Environmental Health Perspectives. 2012;120(3):451-7
  • dc.rights Reproduced with permission from Environmental Health Perspectivesca
  • dc.rights.accessRights info:eu-repo/semantics/openAccessca
  • dc.subject.keyword Body mass indexen
  • dc.subject.keyword Dichlorodiphenyldichloroethylene (DDE)en
  • dc.subject.keyword Dichlorodiphenyltrichloroethane (DDT)en
  • dc.subject.keyword Environmental obesogensen
  • dc.subject.keyword High-fat intakesen
  • dc.subject.keyword Obesityen
  • dc.subject.keyword Persistent organic pollutantsen
  • dc.subject.keyword Polychlorinated biphenyls (PCBs)en
  • dc.subject.other Obesitat en els infantsca
  • dc.subject.other Contaminants persistents -- Toxicologia -- Epidemiologiaca
  • dc.title Prenatal concentrations of polychlorinated biphenyls, DDE, and DDT and overweight in children: a prospective birth cohort studyen
  • dc.type info:eu-repo/semantics/articleca
  • dc.type.version info:eu-repo/semantics/publishedVersionca

Col·leccions

Articles (Departament de Medicina i Ciències de la Vida)
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