Microbial phenolic metabolites are associated with improved cognitive health

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• dc.contributor.author Domínguez-López, Inés
• dc.contributor.author Malcampo, Mireia
• dc.contributor.author Vera, Natàlia
• dc.contributor.author Talens, Natàlia
• dc.contributor.author Fitó Colomer, Montserrat
• dc.contributor.author Lamuela-Raventós, Rosa M.
• dc.date.accessioned 2024-10-29T07:27:48Z
• dc.date.available 2024-10-29T07:27:48Z
• dc.date.issued 2024
• dc.description.abstract Scope: Diets rich in polyphenols has been associated with better cognitive performance. The aim of this study is to assess the relationship between microbial phenolic metabolites (MPM) in urine and cognition in the context of an older population at high cardiovascular risk. Methods and results: A cross-sectional analysis is conducted in 400 individuals of the PREDIMED-Plus study. Liquid chromatography coupled to mass spectrometry is used to identify urinary MPM. Mediterranean diet (MedDiet) adherence is estimated with a 17-item questionnaire and cognitive function is evaluated with a battery of neuropsychological tests. Multivariable-adjusted linear regression models are fitted to assess the relationship of urinary MPM with the MedDiet and cognitive tests. Protocatechuic acid and enterolactone glucuronide are associated with higher adherence to the MedDiet. Regarding cognitive function, protocatechuic acid, vanillic acid glucuronide, 3-hydroxybenzoic acid, enterodiol glucuronide, and enterolactone glucuronide are directly associated with a global composite score of all the cognitive tests. Furthermore, protocatechuic acid and enterolactone glucuronide are associated with higher scores in the Mini-Mental State Examination, whereas enterodiol glucuronide is associated with improved Clock Drawing Test scores. Conclusions: These results suggest that the MedDiet is linked to MPM associated with better cognitive performance in an older population.
• dc.description.sponsorship I.D.-L. thanks the Spanish Ministry of Science Innovation and Universities for the Formación de Profesorado Universitario DFPU20/02478) contract. I.P-M. is thankful for the predoctoral scholarship FI-SDUR (EMC/2703/2019). The authors also thank all the volunteers for their participation in and the personnel for their contribution to the PREDIMED-Plus trial and the CCiT UB facility for the LC-MS/MS equipment support. S.S. is a recipient of the Maria Zambrano Fellowship with funding support from the Ministry of Universities and the Recovery, Transformation and Resilience Plan, Spain. The Fellowship is “Funded by the European Union – NextGenerationEU”. They also thank CERCA Programme/Generalitat de Catalunya for institutional support. This research was funded by PID2020-114022RB-I00 and CIBEROBN from the Instituto de Salud Carlos III, ISCIII from the Ministerio de Ciencia, Innovación y Universidades, (AEI/FEDER, UE), Generalitat de Catalunya (GC) [2021-SGR-00334]. INSA-UB is Maria de Maeztu Unit of Excellence (grant CEX2021-001234-M funded by MICIN/AEI/FEDER, UE. The PREDIMED-Plus trial was first supported by the European Research Council (Advanced Research Grant https://cordis.europa.eu/project/id/340918/ with M.Á.M.-G as PI); and the official Spanish Institutions for funding scientific biomedical research, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn) and Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (four coordinated Fondo de Investigaciones Sanitarias projects led by J.S.-S. and J.V., including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, and PI17/00926), the Special Action Project entitled Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus grant to J.S.-S., the Recercaixa grant to J.S.-S. (2013ACUP00194), grants from the Generalitat Valenciana (PROMETEO/2017/017 and PROMETEO/2021/21), a SEMERGEN grant, Fundació la Marató de TV3 (PI044003), 2017 SGR 1717 from Generalitat de Catalunya, a CICYT grant provided by the Ministerio de Ciencia, Innovación y Universidades (AGL2016-75329-R) a grant from the Ministerio de Ciencia AEI 10.13039/501100011033 and by “ERDF A way of making Europe”: PID2019-108858RB-I00, and funds from the European Regional Development Fund (CB06/03). Food companies Hojiblanca (Lucena, Spain) and Patrimonio Comunal Olivarero (Madrid, Spain) donated extra virgin olive oil, and the Almond Board of California (Modesto, CA, USA), American Pistachio Growers (Fresno, CA, USA), and Paramount Farms (Wonderful Company, LLC, Los Angeles, CA, USA) donated nuts. J.K. was supported by the “FOLIUM” program within the FUTURMed project entitled Talent for the medicine of the future from the Fundació Institut d'Investigació Sanitària Illes Balears. This call was co-financed at 50% with charge to the Operational Program FSE 2014–2020 of the Balearic Islands. This work is partially supported by ICREA under the ICREA Academia programme to J.S-S.
• dc.format.mimetype application/pdf
• dc.identifier.citation Domínguez-López I, Galkina P, Parilli-Moser I, Arancibia-Riveros C, Martínez-González MÁ, Salas-Salvadó J, et al. Microbial phenolic metabolites are associated with improved cognitive health. Mol Nutr Food Res. 2024 Jan;68(2):e2300183. DOI: 10.1002/mnfr.202300183
• dc.identifier.doi http://dx.doi.org/10.1002/mnfr.202300183
• dc.identifier.issn 1613-4125
• dc.identifier.uri http://hdl.handle.net/10230/68381
• dc.language.iso eng
• dc.publisher Wiley
• dc.relation.ispartof Mol Nutr Food Res. 2024 Jan;68(2):e2300183
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2020-114022RB-I00
• dc.rights © 2023 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
• dc.subject.keyword Mediterranean diet
• dc.subject.keyword PREDIMED-Plus
• dc.subject.keyword Bioactive compounds
• dc.subject.keyword Cognition
• dc.subject.keyword Neurodegeneration
• dc.title Microbial phenolic metabolites are associated with improved cognitive health
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion