Safety and efficacy of topically applied selected cutibacterium acnes strains over five weeks in patients with acne vulgaris: an open-label, pilot study

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• dc.contributor.author Koraglan, Ante
• dc.contributor.author Paetzold, Bernhard, 1981-
• dc.contributor.author Pereira de Lima, Joao
• dc.contributor.author Brüggemann, Holger
• dc.contributor.author Tüting, Thomas
• dc.contributor.author Schanze, Denny
• dc.contributor.author Güell Cargol, Marc, 1982-
• dc.contributor.author Gollnick, Harald
• dc.date.accessioned 2020-01-09T08:57:32Z
• dc.date.available 2020-01-09T08:57:32Z
• dc.date.issued 2019
• dc.description.abstract Imbalance in skin microflora, particularly related to certain Cutibacterium acnes strains, may trigger acne. Application of non-acne-causing strains to the skin may modulate the skin microbiome and thereby lead to a reduction in acne. This pilot study evaluates the safety and efficacy of microbiome modulation on acne-prone skin. The study had 2 phases: active induction (5% benzoyl peroxide gel, 7 days) and interventional C. acnes strains treatment (5 weeks). Patients were randomized to either topical skin formulations PT1 (2 strains of C. acnes Single Locus Sequence Typing [SLST] type C3 and K8, 50% each) or PT2 (4 strains of C. acnes SLST type C3 [55%], K8 [5%], A5 [30%] and F4 [10%]). Safety and efficacy was evaluated in 14 patients (PT1=8/14, PT2=6/14). Skin microbiome composition shifted towards study formulations. No untoward adverse events, visible irritation, or significant flare-up were observed. Non-inflamed lesions and skin pH were reduced. Comedone counts improved clinically with no deterioration in inflammatory lesions.
• dc.format.mimetype application/pdf
• dc.identifier.citation Karoglan A, Paetzold B, Pereira de Lima J, Brüggemann H, Tüting T, Schanze D et al. Safety and efficacy of topically applied selected cutibacterium acnes strains over five weeks in patients with acne vulgaris: an open-label, pilot study. Acta Derm Venereol. 2019;99(13):1253-7. DOI: 10.2340/00015555-3323
• dc.identifier.doi http://dx.doi.org/10.2340/00015555-3323
• dc.identifier.issn 0001-5555
• dc.identifier.uri http://hdl.handle.net/10230/43241
• dc.language.iso eng
• dc.publisher Society for Publication of Acta Dermato-Venereologica
• dc.relation.ispartof Acta Dermato-Venereologica. 2019;99(13):1253-7
• dc.rights © 2019 Acta Dermato-Venereologica. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/)
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
• dc.subject.keyword Microbiome
• dc.subject.keyword Skin
• dc.subject.keyword Acne vulgaris
• dc.title Safety and efficacy of topically applied selected cutibacterium acnes strains over five weeks in patients with acne vulgaris: an open-label, pilot study
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion