Somatic and vicarious pain are represented by dissociable multivariate brain patterns.
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- dc.contributor.author Krishnan, Anjalica
- dc.contributor.author Woo, Choong-Wanca
- dc.contributor.author Chang, Luke J.ca
- dc.contributor.author Ruzic, Lukaca
- dc.contributor.author Gu, Xiaosica
- dc.contributor.author López-Solà, Marinaca
- dc.contributor.author Jackson, Philip L.ca
- dc.contributor.author Pujol Martí, Jesús, 1981-ca
- dc.contributor.author Fan, Jinca
- dc.contributor.author Wager, Tor D.ca
- dc.date.accessioned 2017-01-24T11:24:02Z
- dc.date.available 2017-01-24T11:24:02Z
- dc.date.issued 2017
- dc.description.abstract Understanding how humans represent others' pain is critical for understanding pro-social behavior. 'Shared experience' theories propose common brain representations for somatic and vicarious pain, but other evidence suggests that specialized circuits are required to experience others' suffering. Combining functional neuroimaging with multivariate pattern analyses, we identified dissociable patterns that predicted somatic (high versus low: 100%) and vicarious (high versus low: 100%) pain intensity in out-of-sample individuals. Critically, each pattern was at chance in predicting the other experience, demonstrating separate modifiability of both patterns. Somatotopy (upper versus lower limb: 93% accuracy for both conditions) was also distinct, located in somatosensory versus mentalizing-related circuits for somatic and vicarious pain, respectively. Two additional studies demonstrated the generalizability of the somatic pain pattern (which was originally developed on thermal pain) to mechanical and electrical pain, and also demonstrated the replicability of the somatic/vicarious dissociation. These findings suggest possible mechanisms underlying limitations in feeling others' pain, and present new, more specific, brain targets for studying pain empathy.ca
- dc.description.sponsorship Funding : National Institutes of Health, R01MH076136 Tor D Wager. National Institutes of Health, R01DA035484 Tor D Wager. National Institutes of Health, R21MH083164 Jin Fan.
- dc.format.mimetype application/pdfca
- dc.identifier.citation Krishnan A, Woo CW, Chang LJ, Ruzic L, Gu X, López-Solà M. et al. Somatic and vicarious pain are represented by dissociable multivariate brain patterns. Elife. 2016 Jun 14;5. pii: e15166. doi: 10.7554/eLife.15166ca
- dc.identifier.doi http://dx.doi.org/10.7554/eLife.15166
- dc.identifier.issn 2050-084X
- dc.identifier.uri http://hdl.handle.net/10230/27966
- dc.language.iso engca
- dc.publisher eLife Sciences Publicationsca
- dc.relation.ispartof Elife. 2016 Jun 14;5:e15166
- dc.rights © 2016, Krishnan et al/nThis article is distributed under the terms of the https://creativecommons.org/licenses/by/4.0/, which permits unrestricted use and redistribution provided that the original author and source are credited.ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri https://creativecommons.org/licenses/by/4.0/ca
- dc.subject.other Empatiaca
- dc.subject.other Dolorca
- dc.subject.other Neurociència cognitivaca
- dc.title Somatic and vicarious pain are represented by dissociable multivariate brain patterns.ca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca