Cryoballoon ablation for persistent and paroxysmal atrial fibrillation: procedural differences and results from the spanish registry (RECABA)

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  • dc.contributor.author Vallés Gras, Ermengol
  • dc.contributor.author Jiménez, Jesús
  • dc.contributor.author Martí-Almor, Julio
  • dc.contributor.author Toquero, Jorge
  • dc.contributor.author Ormaetxe, Jose Miguel
  • dc.contributor.author Barrera, Alberto
  • dc.contributor.author García-Alberola, Arcadio
  • dc.contributor.author Rubio, José Manuel
  • dc.contributor.author Moriña, Pablo
  • dc.contributor.author Grande, Carlos
  • dc.contributor.author Arcocha, Maria Fé
  • dc.contributor.author Peinado, Rafael
  • dc.contributor.author Cózar, Rocío
  • dc.contributor.author Hernández, Julio
  • dc.contributor.author Pérez-Alvarez, Luisa
  • dc.contributor.author Gaztañaga, Larraitz
  • dc.contributor.author Ferrero-De-Loma-Osorio, Ángel
  • dc.contributor.author Ruiz-Granell, Ricardo
  • dc.contributor.author Villuendas, Roger
  • dc.contributor.author Martínez-Alday, Jesús Daniel
  • dc.date.accessioned 2022-09-28T06:15:36Z
  • dc.date.available 2022-09-28T06:15:36Z
  • dc.date.issued 2022
  • dc.description.abstract Introduction: Cryoballoon ablation (CBA) has become a standard treatment for paroxysmal atrial fibrillation (PaAF) but limited data is available for outcomes in patients with persistent atrial fibrillation (PeAF). Methods: We analyzed the first 944 patients included in the Spanish Prospective Multi-center Observation Post-market Registry to compare characteristics and outcomes of patients undergoing CBA for PeAF versus PaAF. Results: A total of 944 patients (57.8 ± 10.4 years; 70.1% male) with AF (27.9% persistent) were prospectively included from 25 centers. PeAF patients were more likely to have structural heart disease (67.7 vs. 11.4%; p < 0.001) and left atrium dilation (72.6 vs. 43.3%; p < 0.001). CBA of PeAF was less likely to be performed under general anesthesia (10.7 vs. 22.2%; p < 0.001), with an arterial line (32.2 vs. 44.6%; p < 0.001) and assisted transeptal puncture (11.9 vs. 17.9%; p = 0.025). During an application, PeAF patients had a longer time to -30 °C (35.91 ± 14.20 vs. 34.93 ± 12.87 s; p = 0.021) and a colder balloon nadir temperature during vein isolation (-35.04 ± 9.58 vs. -33.61 ± 10.32 °C; p = 0.004), but received fewer bonus freeze applications (30.7 vs. 41.1%; p < 0.001). There were no differences in acute pulmonary vein isolation and procedure-related complications. Overall, 76.7% of patients were free from AF recurrences at 15-month follow-up (78.9% in PaAF vs. 70.9% in PeAF; p = 0.09). Conclusions: Patients with PeAF have a more diseased substrate, and CBA procedures performed in such patients were more simplified, although longer/colder freeze applications were often applied. The acute efficacy/safety profile of CBA was similar between PaAF and PeAF patients, but long-term results were better in PaAF patients.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Vallès E, Jiménez J, Martí-Almor J, Toquero J, Ormaetxe JM, Barrera A, García-Alberola A, Rubio JM, Moriña P, Grande C, Fé Arcocha M, Peinado R, Cózar R, Hernández J, Pérez-Alvarez L, Gaztañaga L, Ferrero-De Loma-Osorio A, Ruiz-Granell R, Villuendas R, Martínez-Alday JD. Cryoballoon ablation for persistent and paroxysmal atrial fibrillation: procedural differences and results from the spanish registry (RECABA). J Clin Med. 2022 Feb 22;11(5):1166. DOI: 10.3390/jcm11051166
  • dc.identifier.doi http://dx.doi.org/10.3390/jcm11051166
  • dc.identifier.issn 2077-0383
  • dc.identifier.uri http://hdl.handle.net/10230/54184
  • dc.language.iso eng
  • dc.publisher MDPI
  • dc.relation.ispartof J Clin Med. 2022 Feb 22;11(5):1166
  • dc.rights © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri https://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Cryoballoon procedure
  • dc.subject.keyword Persistent atrial fibrillation
  • dc.subject.keyword Registry
  • dc.title Cryoballoon ablation for persistent and paroxysmal atrial fibrillation: procedural differences and results from the spanish registry (RECABA)
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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