A unicellular relative of animals generates a layer of polarized cells by actomyosin-dependent cellularization
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- dc.contributor.author Dudin, Omaya
- dc.contributor.author Ondracka, Andrej
- dc.contributor.author Grau Bové, Xavier
- dc.contributor.author Haraldsen, Arthur A. B.
- dc.contributor.author Toyoda, Atsushi
- dc.contributor.author Suga, Hiroshi
- dc.contributor.author Bråte, Jon
- dc.contributor.author Ruiz Trillo, Iñaki
- dc.date.accessioned 2020-05-27T07:12:01Z
- dc.date.available 2020-05-27T07:12:01Z
- dc.date.issued 2019
- dc.description.abstract In animals, cellularization of a coenocyte is a specialized form of cytokinesis that results in the formation of a polarized epithelium during early embryonic development. It is characterized by coordinated assembly of an actomyosin network, which drives inward membrane invaginations. However, whether coordinated cellularization driven by membrane invagination exists outside animals is not known. To that end, we investigate cellularization in the ichthyosporean Sphaeroforma arctica, a close unicellular relative of animals. We show that the process of cellularization involves coordinated inward plasma membrane invaginations dependent on an actomyosin network and reveal the temporal order of its assembly. This leads to the formation of a polarized layer of cells resembling an epithelium. We show that this stage is associated with tightly regulated transcriptional activation of genes involved in cell adhesion. Hereby we demonstrate the presence of a self-organized, clonally-generated, polarized layer of cells in a unicellular relative of animals.
- dc.format.mimetype application/pdf
- dc.identifier.citation Dudin O, Ondracka A, Grau-Bové X, Haraldsen AA, Toyoda A, Suga H, Bråte J, Ruiz-Trillo I. A unicellular relative of animals generates a layer of polarized cells by actomyosin-dependent cellularization. Elife. 2019; 8:e49801. DOI: 10.7554/eLife.49801
- dc.identifier.doi http://dx.doi.org/10.7554/eLife.49801
- dc.identifier.issn 2050-084X
- dc.identifier.uri http://hdl.handle.net/10230/44829
- dc.language.iso eng
- dc.publisher eLife
- dc.relation.ispartof Elife. 2019; 8:e49801
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/616960
- dc.rights © 2019, Dudin et al. This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use and redistribution provided that the original author and source are credited.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Actin
- dc.subject.keyword Cell biology
- dc.subject.keyword Cellularization
- dc.subject.keyword Coenocyte
- dc.subject.keyword Epithelium
- dc.subject.keyword Evolution
- dc.subject.keyword Evolutionary biology
- dc.subject.keyword Multicellularity
- dc.title A unicellular relative of animals generates a layer of polarized cells by actomyosin-dependent cellularization
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion