Reliability of blood eosinophil count in steady-state bronchiectasis
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- dc.contributor.author Martínez-García, Miguel Ángel
- dc.contributor.author Olveira, Casilda
- dc.contributor.author Girón Moreno, Rosa María
- dc.contributor.author García Clemente, Marta Maria
- dc.contributor.author Máiz, Luis
- dc.contributor.author Sibila, Oriol
- dc.contributor.author Golpe, Rafael
- dc.contributor.author Rodríguez Hermosa, Juan Luis
- dc.contributor.author Barreiro Portela, Esther
- dc.contributor.author Méndez, Raúl
- dc.contributor.author Prados, Concepción
- dc.contributor.author Rodríguez-López, Juan
- dc.contributor.author Oscullo, Grace
- dc.contributor.author Rosa Carrillo, David de la
- dc.date.accessioned 2024-11-06T07:17:10Z
- dc.date.available 2024-11-06T07:17:10Z
- dc.date.issued 2024
- dc.description Data de publicació electrònica: 05-01-2024
- dc.description.abstract Rationale: The baseline value of eosinophils in peripheral blood (BEC) has been associated with different degrees of severity, prognosis and response to treatment in patients with bronchiectasis. It is not known, however, if this basal value remains constant over time. Objectives: The aim of this study was to assess whether the BEC remains stable in the long term in patients with bronchiectasis. Methods and measurements: Patients from the RIBRON registry of bronchiectasis diagnosed by computed tomography with at least 2 BEC measurements one year apart were included in the study. Patients with asthma and those taking anti-eosinophilic drugs were excluded. Reliability was assessed using the intra-class correlation coefficient (ICC). A patient with a BEC of at least 300 cells/uL or less than 100 cells/uL was considered eosinophilic or eosinopenic, respectively. Group changes over time were also calculated. Main results: Seven hundred and thirteen patients were finally included, with a mean age of 66.5 (13.2) years (65.8 % women). A total of 2701 BEC measurements were performed, with a median number of measurements per patient of 4 (IQR: 2-5) separated by a median of 12.1 (IQR: 10.5-14.3) months between two consecutive measurements. The ICC was good (>0.75) when calculated between two consecutive measurements (approximately one year apart) but had dropped significantly by the time of the next annual measurements. Similarly, the change from an eosinophilic or eosinopenic patient to a non-eosinophilic or non-eosinopenic patient, respectively, was less than 30 % during the first year with respect to the baseline value but was close to 50 % in later measurements. Conclusions: Given the significant changes observed in the baseline value of the BEC over time, its monitoring is necessary in patients with bronchiectasis in order to more reliably assess its usefulness.
- dc.format.mimetype application/pdf
- dc.identifier.citation Martínez-García MA, Olveira C, Girón R, García-Clemente M, Máiz L, Sibila O, et al. Reliability of blood eosinophil count in steady-state bronchiectasis. Pulmonology. 2024 Jan 4:S2531-0437(23)00204-0. DOI: 10.1016/j.pulmoe.2023.11.006
- dc.identifier.doi http://dx.doi.org/10.1016/j.pulmoe.2023.11.006
- dc.identifier.issn 2531-0429
- dc.identifier.uri http://hdl.handle.net/10230/68448
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Pulmonology. 2024 Jan 4:S2531-0437(23)00204-0
- dc.rights © 2023 Sociedade Portuguesa de Pneumologia. Published by Elsevier España, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
- dc.subject.keyword Bronchiectasis
- dc.subject.keyword Eosinophils
- dc.subject.keyword Exacerbations
- dc.subject.keyword Severity
- dc.title Reliability of blood eosinophil count in steady-state bronchiectasis
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion