Human papillomavirus and breast cancer: no evidence of association in a Spanish set of cases
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- dc.contributor.author Vernet-Tomás, Mariaca
- dc.contributor.author Mena, Marisaca
- dc.contributor.author Alemany, Laiaca
- dc.contributor.author Bravo, Ignacio G.ca
- dc.contributor.author Sanjosé Llongueras, Silvia deca
- dc.contributor.author Nicolau, Pauca
- dc.contributor.author Bergueiro Flor, Albaca
- dc.contributor.author Corominas Torres, Josep Mariaca
- dc.contributor.author Serrano Figueras, Sergica
- dc.contributor.author Carreras Collado, Ramónca
- dc.contributor.author Lloveras Rubio, Belenca
- dc.date.accessioned 2015-06-16T12:01:14Z
- dc.date.available 2015-06-16T12:01:14Z
- dc.date.issued 2015
- dc.description.abstract BACKGROUND/AIM: Great controversy exists about the association between Human Papillomavirus (HPV) and breast tumors. The aim of this study was to explore the presence of HPV DNA in a large set of breast cancer cases. MATERIALS AND METHODS:/nTechniques used followed the standards for an international retrospective survey of HPV-DNA genotyping, coordinated by our own group and the DDL Laboratories in Rijswijk, the Netherlands. Paraffin-embedded samples were used. SPF-10 broad-spectrum primers were applied, followed by deoxyribonucleic acid enzyme immunoassay and genotyping by reverse-line probe assay./nRESULTS: A total of 78 samples were included in the study, 2 of benign conditions and 76 carcinomas, including different histological subtypes. HPV was not present in any of the specimens studied irrespective of histology, hormonal status and stage of disease. CONCLUSION: Our data do not support the involvement of HPV in breast carcinogenesis as no evidence of its presence was found.ca
- dc.description.sponsorship This research was funded by the internal resources of the departments involved (Breast Functional Unit, Obstetrics and Gynaecology Department and Pathology Department from Hospital del Mar; and IDIBELL from Catalan Institute of Oncology) ;sample processing at IDIBELL institute was partially funded by resources from a grant from Lilly foundation( Premio de Investigación Biomédica Preclínica /n2012 F. Xavier Bosch)
- dc.format.mimetype application/pdfca
- dc.identifier.citation Vernet-Tomas M, Mena M2, Alemany L3, Bravo I, De Sanjosé S, Nicolau P. et al. Human papillomavirus and breast cancer: no evidence of association in a Spanish set of cases. Anticancer Res. 2015 Feb;35(2):851-6.ca
- dc.identifier.issn 0250-7005
- dc.identifier.uri http://hdl.handle.net/10230/23836
- dc.language.iso engca
- dc.publisher International Institute of Anticancer Research ca
- dc.relation.ispartof Anticancer Research. 2015 Feb;35(2):851-6
- dc.rights c) 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All reighs reserved.ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.keyword Breast cancer
- dc.subject.keyword Human papillomavirus
- dc.subject.keyword Polymerase chain reaction
- dc.title Human papillomavirus and breast cancer: no evidence of association in a Spanish set of casesca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/acceptedVersionca