Exposure to endocrine-disrupting chemicals during pregnancy and weight at 7 years of age: a multi-pollutant approach.

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• dc.contributor.author Agay-Shay, Kerenca
• dc.contributor.author Martínez Muriano, Davidca
• dc.contributor.author Valvi, Damaskini, 1983-ca
• dc.contributor.author García Esteban, Raquelca
• dc.contributor.author Basagaña Flores, Xavierca
• dc.contributor.author Robinson, Oliverca
• dc.contributor.author Casas Sanahuja, Maribelca
• dc.contributor.author Sunyer Deu, Jordica
• dc.contributor.author Vrijheid, Martineca
• dc.date.accessioned 2015-11-25T08:15:01Z
• dc.date.available 2015-11-25T08:15:01Z
• dc.date.issued 2015
• dc.description.abstract BACKGROUND: Prenatal exposure to endocrine-disrupting chemicals (EDCs) may induce weight gain and obesity in children, but the obesogenic effects of mixtures have not been studied. OBJECTIVE: We evaluated the associations between pre- and perinatal biomarker concentrations of 27 EDCs and child weight status at 7 years of age. METHODS: In pregnant women enrolled in a Spanish birth cohort study between 2004 and 2006, we measured the concentrations of 10 phthalate metabolites, bisphenol A, cadmium, arsenic, and lead in two maternal pregnancy urine samples; 6 organochlorine compounds in maternal pregnancy serum; mercury in cord blood; and 6 polybrominated diphenyl ether congeners in colostrum. Among 470 children at 7 years, body mass index (BMI) z-scores were calculated, and overweight was defined as BMI > 85th percentile. We estimated associations with EDCs in single-pollutant models and applied principal-component analysis (PCA) on the 27 pollutant concentrations. RESULTS: In single-pollutant models, HCB (hexachlorobenzene), βHCH (β-hexachlorocyclohexane), and polychlorinated biphenyl (PCB) congeners 138 and 180 were associated with increased child BMI z-scores; and HCB, βHCH, PCB-138, and DDE (dichlorodiphenyldichloroethylene) with overweight risk. PCA generated four factors that accounted for 43.4% of the total variance. The organochlorine factor was positively associated with BMI z-scores and with overweight (adjusted RR, tertile 3 vs. 1: 2.59; 95% CI: 1.19, 5.63), and these associations were robust to adjustment for other EDCs. Exposure in the second tertile of the phthalate factor was inversely associated with overweight. CONCLUSIONS: Prenatal exposure to organochlorines was positively associated with overweight at age 7 years in our study population. Other EDCs exposures did not confound this association.ca
• dc.description.sponsorship This study was funded by grants from Instituto de Salud Carlos III (Red INMA G03/176, CB06/02/0041), Spanish Ministry of Health (FIS-PI12/01890, FIS-PI041436, FIS-PI081151), Generalitat de Catalunya (CIRIT 1999SGR 00241), and RecerCaixa (register number 2010ACUP00349). A full roster of the INMA Project Investigators can be found online (http://www.proyectoinma.org). The study was supported by a postdoctoral fellowship to K.A.-S. from the Environment and Health Fund (EHF, Israel). The authors declare they have no actual or potential competing financial interests
• dc.format.mimetype application/pdfca
• dc.identifier.citation Agay-Shay K, Martinez D, Valvi D, Garcia-Esteban R, Basagaña X, Robinson O. et al. Exposure to Endocrine-Disrupting Chemicals during Pregnancy and Weight at 7 Years of Age: A Multi-pollutant Approach. Environ Health Perspect. 2015 Oct;123(10):1030-7. DOI: 10.1289/ehp.1409049.ca
• dc.identifier.doi http://dx.doi.org/10.1289/ehp.1409049
• dc.identifier.issn 0091-6765
• dc.identifier.uri http://hdl.handle.net/10230/25202
• dc.language.iso engca
• dc.publisher National Institute of Environmental Health Sciencesca
• dc.relation.ispartof Environ Health Perspect. 2015 Oct;123(10):1030-7
• dc.rights Reproduced with permission from Environmental Health Perspectivesca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.subject.other Contaminació -- Aspectes ambientalsca
• dc.subject.other Embaràsca
• dc.title Exposure to endocrine-disrupting chemicals during pregnancy and weight at 7 years of age: a multi-pollutant approach.ca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersionca