Protein Syndesmos is a novel RNA-binding protein that regulates primary cilia formation

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Avolio, Rosario
• dc.contributor.author Järvelin, Aino I.
• dc.contributor.author Mohammed, Shabaz
• dc.contributor.author Agliarulo, Ilenia
• dc.contributor.author Condelli, Valentina
• dc.contributor.author Zoppoli, Pietro
• dc.contributor.author Calice, Giovanni
• dc.contributor.author Sarnataro, Daniela
• dc.contributor.author Bechara, Elias
• dc.contributor.author Tartaglia, Gian Gaetano
• dc.contributor.author Landriscina, Matteo
• dc.contributor.author Castello, Alfredo
• dc.contributor.author Esposito, Franca
• dc.contributor.author Matassa, Danilo Swann
• dc.date.accessioned 2019-11-27T08:34:25Z
• dc.date.available 2019-11-27T08:34:25Z
• dc.date.issued 2018
• dc.description.abstract Syndesmos (SDOS) is a functionally poorly characterized protein that directly interacts with p53 binding protein 1 (53BP1) and regulates its recruitment to chromatin. We show here that SDOS interacts with another important cancer-linked protein, the chaperone TRAP1, associates with actively translating polyribosomes and represses translation. Moreover, we demonstrate that SDOS directly binds RNA in living cells. Combining individual gene expression profiling, nucleotide crosslinking and immunoprecipitation (iCLIP), and ribosome profiling, we discover several crucial pathways regulated post-transcriptionally by SDOS. Among them, we identify a small subset of mRNAs responsible for the biogenesis of primary cilium that have been linked to developmental and degenerative diseases, known as ciliopathies, and cancer. We discover that SDOS binds and regulates the translation of several of these mRNAs, controlling cilia development.
• dc.format.mimetype application/pdf
• dc.identifier.citation Avolio R, Järvelin AI, Mohammed S, Agliarulo I, Condelli V, Zoppoli P, Calice G, Sarnataro D, Bechara E, Tartaglia GG, Landriscina M, Castello A, Esposito F, Matassa DS. Protein Syndesmos is a novel RNA-binding protein that regulates primary cilia formation. Nucleic Acids Res. 2018; 46(22):12067-12086. DOI 10.1093/nar/gky873
• dc.identifier.doi http://dx.doi.org/10.1093/nar/gky873
• dc.identifier.issn 0305-1048
• dc.identifier.uri http://hdl.handle.net/10230/43002
• dc.language.iso eng
• dc.publisher Oxford University Press
• dc.relation.ispartof Nucleic Acids Res. 2018; 46(22):12067-12086
• dc.rights © The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword RNA
• dc.subject.keyword RNA-protein complexes
• dc.title Protein Syndesmos is a novel RNA-binding protein that regulates primary cilia formation
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion