Accelerated redevelopment of vocal skills is preceded by lasting reorganization of the song motor circuitry

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• dc.contributor.author Vellema, Michiel
• dc.contributor.author Diales Rocha, Mariana
• dc.contributor.author Bascones Gleave, Sabrina, 1985-
• dc.contributor.author Zsebők, Sándor
• dc.contributor.author Dreier, Jes
• dc.contributor.author Leitner, Stefan
• dc.contributor.author Van der Linden, Annemie
• dc.contributor.author Brewer, Jonathan
• dc.contributor.author Gahr, Manfred
• dc.date.accessioned 2019-12-05T08:36:15Z
• dc.date.available 2019-12-05T08:36:15Z
• dc.date.issued 2019
• dc.description.abstract Complex motor skills take considerable time and practice to learn. Without continued practice the level of skill performance quickly degrades, posing a problem for the timely utilization of skilled motor behaviors. Here we quantified the recurring development of vocal motor skills and the accompanying changes in synaptic connectivity in the brain of a songbird, while manipulating skill performance by consecutively administrating and withdrawing testosterone. We demonstrate that a songbird with prior singing experience can significantly accelerate the re-acquisition of vocal performance. We further demonstrate that an increase in vocal performance is accompanied by a pronounced synaptic pruning in the forebrain vocal motor area HVC, a reduction that is not reversed when birds stop singing. These results provide evidence that lasting synaptic changes in the motor circuitry are associated with the savings of motor skills, enabling a rapid recovery of motor performance under environmental time constraints.
• dc.description.sponsorship This paper was supported by the following grants: Horizon 2020 Framework Programme 701660 to Michiel Vellema. National Research, Development and Innovation Office Hungary K-115970 to Sándor Zsebők. Interuniversity Attraction Poles IUAP-NIMI-P6/38 to Annemie Van der Linden. Max-Planck-Gesellschaft Open-access funding to Manfred Gahr. National Research, Development and Innovation Office Hungary K-129215 to Sándor Zsebők. National Research, Development and Innovation Office Hungary PD-115730 to Sándor Zsebők.
• dc.format.mimetype application/pdf
• dc.identifier.citation Vellema M, Diales Rocha M, Bascones S, Zsebők S, Dreier J, Leitner S. et al. Accelerated redevelopment of vocal skills is preceded by lasting reorganization of the song motor circuitry. Elife. 2019 May 17;8. pii: e43194. DOI 10.7554/eLife.43194
• dc.identifier.doi http://dx.doi.org/10.7554/eLife.43194
• dc.identifier.issn 2050-084X
• dc.identifier.uri http://hdl.handle.net/10230/43096
• dc.language.iso eng
• dc.publisher eLife
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/701660
• dc.rights Copyright © 2019, Vellema et al. This article is distributed under the terms of the Creative Commons Attribution License, https://creativecommons.org/licenses/by/4.0/, which permits unrestricted use and redistribution provided that the original author and source are credited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Birdsong
• dc.subject.keyword Brain development
• dc.subject.keyword Canary
• dc.subject.keyword Dendritic spines
• dc.subject.keyword Neuroscience
• dc.subject.keyword Savings
• dc.subject.keyword Skill re-acquisition
• dc.title Accelerated redevelopment of vocal skills is preceded by lasting reorganization of the song motor circuitry
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion