Effects of high-fat diet and maternal binge-like alcohol consumption and their influence on cocaine response in female mice offspring

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• dc.contributor.author Duart Castells, Leticia
• dc.contributor.author Cantacorps Centellas, Lídia, 1991-
• dc.contributor.author López Arnau, Raúl
• dc.contributor.author Montagud-Romero, Sandra
• dc.contributor.author Puster, Brigitte
• dc.contributor.author Mera, Paula
• dc.contributor.author Serra, Dolors
• dc.contributor.author Camarasa, Jordi
• dc.contributor.author Pubill, David
• dc.contributor.author Valverde Granados, Olga
• dc.contributor.author Escubedo, Elena
• dc.date.accessioned 2021-03-12T06:48:14Z
• dc.date.available 2021-03-12T06:48:14Z
• dc.date.issued 2021
• dc.description.abstract Background: Prenatal alcohol exposure is a leading cause of neurobehavioral and neurocognitive deficits collectively known as fetal alcohol spectrum disorders, including eating disorders and increased risk for substance abuse as very common issues. In this context, the present study aimed to assess the interaction between prenatal and lactation alcohol exposure (PLAE) and a high-fat diet (HFD) during childhood and adolescence. Methods: Pregnant C57BL/6 mice underwent a procedure for alcohol binge drinking during gestation and lactation periods. Subsequently, PLAE female offspring were fed with an HFD for 8 weeks, and thereafter, nutrition-related parameters as well as their response to cocaine were assessed. Results: In our model, feeding young females with an HFD increased their triglyceride blood levels but did not induce overweight compared with those fed with a standard diet. Moreover, PLAE affected how females responded to the fatty diet as they consumed less food than water-exposed offspring, consistent with a lower gain of body weight. HFD increased the psychostimulant effects of cocaine. Surprisingly, PLAE reduced the locomotor responses to cocaine without modifying cocaine-induced reward. Moreover, PLAE prevented the striatal overexpression of cannabinoid 1 receptors induced by an HFD and induced an alteration of myelin damage biomarker in the prefrontal cortex, an effect that was mitigated by an HFD-based feeding. Conclusion: Therefore, in female offspring, some effects triggered by one of these factors, PLAE or an HFD, were blunted by the other, suggesting a close interaction between the involved mechanisms.
• dc.description.sponsorship This study was supported by Ministerio de Economia y Competitividad (grant nos. SAF2016-46135-R, SAF2016-75966-R-FEDER, SAF2017-83813-C3-1-R), Ministerio de Sanidad, Asuntos Sociales e Igualdad (Retic-ISCIII, RD16/017/010), and Plan Nacional sobre Drogas 2018I007, 2016I004). Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN) (grant CB06/03/0001 to D.S.). Fundació LaMarató de TV3 (grant 201627–30 to D.S.). L.D.C. received FPU grants from the Ministerio de Economía y Competitividad (15/02492). J.C., D.P., R.L.A., and E.E. belong to institutionally-recognized research consolidated groups 2017SGR979 and O.V. to 2017SGR109. The funding sources had no further involvement in the study.
• dc.format.mimetype application/pdf
• dc.identifier.citation Duart-Castells L, Cantacorps L, López-Arnau R, Montagud-Romero S, Puster B, Mera P, Serra D, Camarasa J, Pubill D, Valverde O, Escubedo E. Effects of high-fat diet and maternal binge-like alcohol consumption and their influence on cocaine response in female mice offspring. Int J Neuropsychopharmacol. 2021; 24(1):77-88. DOI: 10.1093/ijnp/pyaa074
• dc.identifier.doi http://dx.doi.org/10.1093/ijnp/pyaa074
• dc.identifier.issn 1461-1457
• dc.identifier.uri http://hdl.handle.net/10230/46737
• dc.language.iso eng
• dc.publisher Oxford University Press
• dc.relation.ispartof Int J Neuropsychopharmacol. 2021; 24(1):77-88
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2016-46135-R
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2016-75966-R
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/SAF2017-83813-C3-1-R
• dc.rights © The Author(s) 2020. Published by Oxford University Press on behalf of CINP. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
• dc.subject.keyword Alcohol
• dc.subject.keyword Cocaine
• dc.subject.keyword Drinking-in-the-dark
• dc.subject.keyword Female
• dc.subject.keyword High-fat diet
• dc.title Effects of high-fat diet and maternal binge-like alcohol consumption and their influence on cocaine response in female mice offspring
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion