Vitamin D and the epithelial to mesenchymal transition
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- dc.contributor.author Larriba, María Jesúsca
- dc.contributor.author García de Herreros, Antonioca
- dc.contributor.author Muñoz, Albertoca
- dc.date.accessioned 2016-04-28T10:34:18Z
- dc.date.available 2016-04-28T10:34:18Z
- dc.date.issued 2016
- dc.description.abstract Several studies support reciprocal regulation between the active vitamin D derivative 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) and the epithelial to mesenchymal transition (EMT). Thus, 1,25(OH)2D3 inhibits EMT via the induction of a variety of target genes that encode cell adhesion and polarity proteins responsible for the epithelial phenotype and through the repression of key EMT inducers. Both direct and indirect regulatory mechanisms mediate these effects. Conversely, certain master EMT inducers inhibit 1,25(OH)2D3 action by repressing the transcription of VDR gene encoding the high affinity vitamin D receptor that mediates 1,25(OH)2D3 effects. Consequently, the balance between the strength of 1,25(OH)2D3 signaling and the induction of EMT defines the cellular phenotype in each context. Here we review the current understanding of the genes and mechanisms involved in the interplay between 1,25(OH)2D3 and EMT.ca
- dc.description.sponsorship The work in the authors’ laboratories is supported by Ministerio de Econom´ıa y Competitividad of Spain-Fondo Europeo de Desarrollo Regional (FEDER) to Alberto Munoz (SAF2013- ˜ 43468-R), Instituto de Salud Carlos III-FEDER to Alberto Munoz (RD12/0036/0021) and Antonio García de Herreros (RD12/0036/0005), and Comunidad de Madrid to Alberto Muñoz and Antonio García de Herreros (S2010/BMD-2344 Colomics2).
- dc.format.mimetype application/pdfca
- dc.identifier.citation Larriba MJ, García de Herreros A, Muñoz A. Vitamin D and the epithelial to mesenchymal transition. Stem Cells Int. 2016;2016:6213872. DOI: 10.1155/2016/6213872ca
- dc.identifier.doi http://dx.doi.org/10.1155/2016/6213872
- dc.identifier.issn 1687-966X
- dc.identifier.uri http://hdl.handle.net/10230/26203
- dc.language.iso engca
- dc.publisher Hindawi Publishing Corporationca
- dc.relation.ispartof Stem Cells International. 2016;2016:6213872
- dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2013-43468-R
- dc.rights Copyright © 2016 María Jesús Larriba et al. This is an open access article distributed under the http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/ca
- dc.subject.other Vitamina Dca
- dc.subject.other Cèl·lules epitelials -- Aspectes genèticsca
- dc.title Vitamin D and the epithelial to mesenchymal transitionca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca