Rationale and population-based prospective cohort protocol for the disadvantaged populations at risk of decline in eGFR (CO-DEGREE)

González Quiroz, Marvin; Nitsch, Dorothea; Hamilton, Sophie; O'Callaghan-Gordo, Cristina; Saran, Rajiv; Glaser, Jason; Correa Rotter, Ricardo; Jakobsson, Kristina; Singh, Ajay; Gunawardena, Nalika; Levin, Adeera; Remuzzi, Giuseppe; Caplin, Ben; Pearce, Neil E.; DEGREE Study Steering Committee

Rationale and population-based prospective cohort protocol for the disadvantaged populations at risk of decline in eGFR (CO-DEGREE)

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dc.contributor.author González Quiroz, Marvin
dc.contributor.author Nitsch, Dorothea
dc.contributor.author Hamilton, Sophie
dc.contributor.author O'Callaghan-Gordo, Cristina
dc.contributor.author Saran, Rajiv
dc.contributor.author Glaser, Jason
dc.contributor.author Correa Rotter, Ricardo
dc.contributor.author Jakobsson, Kristina
dc.contributor.author Singh, Ajay
dc.contributor.author Gunawardena, Nalika
dc.contributor.author Levin, Adeera
dc.contributor.author Remuzzi, Giuseppe
dc.contributor.author Caplin, Ben
dc.contributor.author Pearce, Neil E.
dc.contributor.author DEGREE Study Steering Committee
dc.date.accessioned 2020-05-26T07:37:44Z
dc.date.available 2020-05-26T07:37:44Z
dc.date.issued 2019
dc.description.abstract Introduction: A recently recognised form of chronic kidney disease (CKD) of unknown origin (CKDu) is afflicting communities, mostly in rural areas in several regions of the world. Prevalence studies are being conducted in a number of countries, using a standardised protocol, to estimate the distribution of estimated glomerular filtration rate (eGFR), and thus identify communities with a high prevalence of reduced glomerular filtration rate (GFR). In this paper, we propose a standardised minimum protocol for cohort studies in high-risk communities aimed at investigating the incidence of, and risk factors for, early kidney dysfunction. Methods and analysis: This generic cohort protocol provides the information to establish a prospective population-based cohort study in low-income settings with a high prevalence of CKDu. This involves a baseline survey that included key elements from the DEGREE survey (eg, using the previously published DEGREE methodology) of a population-representative sample, and subsequent follow-up visits in young adults (without a pre-existing diagnosis of CKD (eGFR<60 mL/min/1.73m2), proteinuria or risk factors for CKD at baseline) over several years. Each visit involves a core questionnaire, and collection and storage of biological samples. Local capacity to measure serum creatinine will be required so that immediate feedback on kidney function can be provided to participants. After completion of follow-up, repeat measures of creatinine should be conducted in a central laboratory, using reference standards traceable to isotope dilution mass spectrometry (IDMS) quality control material to quantify the main outcome of eGFR decline over time, alongside a description of the early evolution of disease and risk factors for eGFR decline. Ethics and dissemination: Ethical approval will be obtained by local researchers, and participants will provide informed consent before the study commences. Participants will typically receive feedback and advice on their laboratory results, and referral to a local health system where appropriate.
dc.format.mimetype application/pdf
dc.identifier.citation Gonzalez-Quiroz M, Nitsch D, Hamilton S, O'Callaghan Gordo C, Saran R, Glaser J, Correa-Rotter R, Jakobsson K, Singh A, Gunawardena N, Levin A, Remuzzi G, Caplin B, Pearce N; DEGREE Study Steering Committee. Rationale and population-based prospective cohort protocol for the disadvantaged populations at risk of decline in eGFR (CO-DEGREE). BMJ Open. 2019; 9(9):e031169. DOI: 10.1136/bmjopen-2019-031169
dc.identifier.doi http://dx.doi.org/10.1136/bmjopen-2019-031169
dc.identifier.issn 2044-6055
dc.identifier.uri http://hdl.handle.net/10230/44805
dc.language.iso eng
dc.publisher BMJ Publishing Group
dc.relation.ispartof BMJ Open. 2019; 9(9):e031169
dc.rights © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject.keyword Chronic kidney disease of unknown aetiology
dc.subject.keyword Decline in kidney function
dc.subject.keyword Generic cohort protocol
dc.subject.keyword Prospective cohort study
dc.title Rationale and population-based prospective cohort protocol for the disadvantaged populations at risk of decline in eGFR (CO-DEGREE)
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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