Drug Interactions With New Synthetic Opioids

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• dc.contributor.author Pérez Mañá, Clara
• dc.contributor.author Papaseit Fontanet, Esther
• dc.contributor.author Fonseca Casals, Francina, 1972-
• dc.contributor.author Farré Martínez, Adriana
• dc.contributor.author Torrens, Marta
• dc.contributor.author Farré Albaladejo, Magí
• dc.date.accessioned 2019-04-30T07:49:37Z
• dc.date.available 2019-04-30T07:49:37Z
• dc.date.issued 2018
• dc.description.abstract Fentanyl, fentanyl analogs, and other new synthetic opioids (NSO) have burst onto the illegal drug market as new psychoactive substances (NPS). They are often sold as heroin to unsuspecting users and produce euphoria through their agonist action on μ- opioid receptors. Their high consumption, often combined with other substances, has led to multiple intoxications during recent years. In some countries, such as the United States, the consumption of opioids, whether for medical or recreational purposes, has become epidemic and is considered a public health problem. Fentanyl analogs are more potent than fentanyl which in turn is 50 times more potent than morphine. Furthermore, some fentanyl analogs have longer duration of action and therefore interactions with other substances and medicines can be more serious. This review is focused on the potentially most frequent interactions of opioid NPS taking into account the drugs present in the reported cases of poly-intoxication, including other illegal drugs of abuse and medication. Substances involved are mainly antidepressants, antihistamines, antipsychotics, benzodiazepines, analgesics, anesthetics, psychostimulants, other opioids, alcohol, and illegal drugs of abuse. The interactions can be produced due to pharmacokinetic and pharmacodynamic mechanisms. Naloxone can be used as an antidote, although required doses might be higher than for traditional opioid intoxications. It is crucial that doctors who habitually prescribe opioids, which are often misused by patients and NPS users, be aware of designer opioids' potentially life-threatening drug-drug interactions in order to prevent new cases of intoxication.
• dc.format.mimetype application/pdf
• dc.identifier.citation Pérez-Mañá C, Papaseit E, Fonseca F, Farré A, Torrens M, Farré M. Drug Interactions With New Synthetic Opioids. Front Pharmacol. 2018 Oct 11;9:1145. DOI: 10.3389/fphar.2018.01145
• dc.identifier.doi http://dx.doi.org/10.3389/fphar.2018.01145
• dc.identifier.issn 1663-9812
• dc.identifier.uri http://hdl.handle.net/10230/37155
• dc.language.iso eng
• dc.publisher Frontiers
• dc.relation.ispartof Frontiers in Pharmacology. 2018 Oct 11;9:1145
• dc.rights Copyright © 2018 Pérez-Mañá, Papaseit, Fonseca, Farré, Torrens and Farré. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). https://creativecommons.org/licenses/by/4.0/. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Fentanyl
• dc.subject.keyword Fentanyl analogs
• dc.subject.keyword Interaction
• dc.subject.keyword New psychoactive substances
• dc.subject.keyword New synthetic opioids
• dc.subject.other Opiacis
• dc.subject.other Medicaments -- Interacció
• dc.title Drug Interactions With New Synthetic Opioids
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion