How large is the periablational zone after radiofrequency and microwave ablation? Computer-based comparative study of two currently used clinical devices

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• dc.contributor.author Trujillo Guillén, Macarena
• dc.contributor.author Prakash, Punit
• dc.contributor.author Faridi, Pegah
• dc.contributor.author Radosevic, Aleksandar, 1974-
• dc.contributor.author Curto, Sergio
• dc.contributor.author Burdío Pinilla, Fernando
• dc.contributor.author Berjano, Enrique J.
• dc.date.accessioned 2021-02-26T06:59:57Z
• dc.date.available 2021-02-26T06:59:57Z
• dc.date.issued 2020
• dc.description.abstract Purpose: To compare the size of the coagulation (CZ) and periablational (PZ) zones created with two commercially available devices in clinical use for radiofrequency (RFA) and microwave ablation (MWA), respectively. Methods: Computer models were used to simulate RFA with a 3-cm Cool-tip applicator and MWA with an Amica-Gen applicator. The Arrhenius model was used to compute the damage index (Ω). CZ was considered when Ω > 4.6 (>99% of damaged cells). Regions with 0.6<Ω < 2.1 were considered as the PZ (tissue that has undergone moderate sub-ablative hyperthermia). The ratio of PZ volume to CZ volume (PZ/CZ) was regarded as a measure of performance, since a low value implies achieving a large CZ while keeping the PZ small. Results: Ten-min RFA (51 W) created smaller periablational zones than 10-min MWA (11.3 cm3 vs. 17.2-22.9 cm3, for 60-100 W MWA, respectively). Prolonging duration from 5 to 10 min increased the PZ in MWA more than in RFA (2.7 cm3 for RFA vs. 8.3-11.9 cm3 for 60-100 W MWA, respectively). PZ/CZ for RFA were relatively high (65-69%), regardless of ablation time, while those for MWA were highly dependent on the duration (increase of up to 25% between 5 and 10 min) and on the applied power (smaller values as power was raised, 102% for 60 W vs. 81% for 100 W, both for 10 min). The lowest PZ/CZ across all settings was 56%, obtained with 100 W-5 min MWA. Conclusions: Although RFA creates smaller periablational zones than MWA, 100 W-5 min MWA provides the lowest PZ/CZ.
• dc.description.sponsorship This work was supported by the Spanish Ministerio de Ciencia, Innovación y Universidades under “Programa Estatal de I + D + i Orientada a los Retos de la Sociedad”, Grant N° “RTI2018-094357-B-C21”. Punit Prakash acknowledges support from NIH grant R01EB028848. This project has also received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 845645.
• dc.format.mimetype application/pdf
• dc.identifier.citation Trujillo M, Prakash P, Faridi P, Radosevic A, Curto S, Burdio F, Berjano E. How large is the periablational zone after radiofrequency and microwave ablation? Computer-based comparative study of two currently used clinical devices. Int J Hyperthermia. 2020; 37(1):1131-8. DOI: 10.1080/02656736.2020.1823022
• dc.identifier.doi http://dx.doi.org/10.1080/02656736.2020.1823022
• dc.identifier.issn 0265-6736
• dc.identifier.uri http://hdl.handle.net/10230/46593
• dc.language.iso eng
• dc.publisher Taylor & Francis
• dc.relation.ispartof Int J Hyperthermia. 2020; 37(1):1131-8
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/845645
• dc.rights © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Microwave ablation
• dc.subject.keyword Moderate hyperthermic heating
• dc.subject.keyword Periablational zone
• dc.subject.keyword Radiofrequency ablation
• dc.subject.keyword Thermal ablation
• dc.subject.keyword Tumor ablation
• dc.title How large is the periablational zone after radiofrequency and microwave ablation? Computer-based comparative study of two currently used clinical devices
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion