Gastrointestinal physiological changes and their relationship to weight loss following the POSE procedure
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- dc.contributor.author Espinós, J. C.ca
- dc.contributor.author Turró, R.ca
- dc.contributor.author Moragas, G.ca
- dc.contributor.author Bronstone, Amyca
- dc.contributor.author Buchwald, J.N.ca
- dc.contributor.author Mearin, Fermínca
- dc.contributor.author Mata Llorca, Aida de laca
- dc.contributor.author Uchima, H.ca
- dc.contributor.author Turró, J.ca
- dc.contributor.author Delgado Aros, Silviaca
- dc.date.accessioned 2016-05-19T08:04:45Z
- dc.date.issued 2016
- dc.description.abstract BACKGROUND: Primary Obesity Surgery Endolumenal (POSE) is a novel bariatric endoscopic procedure that has been shown to reduce weight safely through 12 months. The study investigated potential mechanisms of weight loss following POSE. METHODS: Patients with class I-II obesity received transmural plications in the gastric fundus and distal gastric body. Patients were evaluated at baseline and at 2- and 6-month follow-up with gastric-emptying (GE) scintigraphy, a validated test of intake capacity (kcal) and plasma glucose homeostasis hormones/gastrointestinal peptides. Weight was recorded through 15 months. Mean data and 95 % CIs are reported. Regression modeling assessed variables that influenced total weight loss (%TWL) and excess weight loss (%EWL). RESULTS: POSE was performed on 18 patients (14 F/4 M); mean age 39 years (34-44), body mass index (BMI, kg/m(2)) 36 (95 % CI, 35; 37). At 15 months (n = 15), mean TWL was 19.1 ± 6.6 % (15.5; 22.8) and EWL was 63.7 ± 25.1 % (49.8; 77.6). At 2 and 6 months (n = 18), intake capacity decreased significantly from 901 (685; 1117) to 473 (345; 600) and 574 kcal (418; 730), respectively (p < 0.001). At 2 months, GE was delayed but returned to baseline levels at 6 months (n = 18). Glucose/insulin ratio improved (p < 0.05). Postprandial decrease in ghrelin was enhanced (p = 0.03) as well as postprandial increase in PYY (p = 0.001). The best model for EWL prediction 15 months after POSE (R (2): 66 %, p = 0.006) included pre-POSE BMI, post-POSE GE, and postprandial PYY increase. CONCLUSIONS: The POSE procedure was followed by significant sustained weight loss and improved glucose homeostasis and satiation peptide responses. Weight loss following POSE may be mediated through changes in gastrointestinal neuro-endocrine physiology.ca
- dc.description.sponsorship Manuscript development was financially supported by USGI Medical, Inc., USA
- dc.format.mimetype application/pdfca
- dc.identifier.citation Espinós JC, Turró R, Moragas G, Bronstone A, Buchwald JN, Mearin F. Gastrointestinal physiological changes and their relationship to weight loss following the POSE procedure. Obes Surg. 2016 May;26(5):1081-9. doi: 10.1007/s11695-015-1863-8.ca
- dc.identifier.doi http://dx.doi.org/10.1007/s11695-015-1863-8
- dc.identifier.issn 0960-8923
- dc.identifier.uri http://hdl.handle.net/10230/26299
- dc.language.iso engca
- dc.publisher Springerca
- dc.relation.ispartof Obesity Surgery. 2016 May;26(5):1081-9
- dc.rights c) Springer (The original publication is available at www.springerlink.com)ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.other Obesitat -- Cirurgiaca
- dc.subject.other Homeòstasica
- dc.subject.other Hormonesca
- dc.subject.other Aprimamentca
- dc.title Gastrointestinal physiological changes and their relationship to weight loss following the POSE procedureca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/acceptedVersionca