Mediterranean diet and physical activity decrease the initiation of cardiovascular drug use in high cardiovascular risk individuals: a cohort study

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• dc.contributor.author Ribó Coll, Margarita
• dc.contributor.author Castro-Barquero, Sara
• dc.contributor.author Lassale, Camille
• dc.contributor.author Sacanella, Emilio
• dc.contributor.author Ros, Emilio
• dc.contributor.author Toledo, Estefania
• dc.contributor.author Sorlí, José Vicente
• dc.contributor.author Díaz López, Andrés
• dc.contributor.author Lapetra, José
• dc.contributor.author Muñoz-Bravo, Carlos
• dc.contributor.author Arós, Fernando
• dc.contributor.author Fiol, Miquel
• dc.contributor.author Serra Majem, Lluís
• dc.contributor.author Pinto, Xavier
• dc.contributor.author Castañer, Olga
• dc.contributor.author Fernández Lázaro, César I.
• dc.contributor.author Portolés, Olga
• dc.contributor.author Babio, Nancy
• dc.contributor.author Estruch, Ramón
• dc.contributor.author Hernáez, Álvaro
• dc.date.accessioned 2021-08-31T06:30:31Z
• dc.date.available 2021-08-31T06:30:31Z
• dc.date.issued 2021
• dc.description.abstract Our aim was to assess whether long-term adherence to a Mediterranean diet (MedDiet) and leisure-time physical activity (LTPA) were associated with a lower initiation of cardiovascular drug use. We studied the association between cumulative average of MedDiet adherence and LTPA and the risk of cardiovascular drug initiation in older adults at high cardiovascular risk (PREvención con DIeta MEDiterránea trial participants) non-medicated at baseline: glucose-lowering drugs (n = 4437), antihypertensives (n = 2145), statins (n = 3977), fibrates (n = 6391), antiplatelets (n = 5760), vitamin K antagonists (n = 6877), antianginal drugs (n = 6837), and cardiac glycosides (n = 6954). One-point increases in MedDiet adherence were linearly associated with a decreased initiation of glucose-lowering (HR: 0.76 [0.71-0.80]), antihypertensive (HR: 0.79 [0.75-0.82]), statin (HR: 0.82 [0.78-0.85]), fibrate (HR: 0.78 [0.68-0.89]), antiplatelet (HR: 0.79 [0.75-0.83]), vitamin K antagonist (HR: 0.83 [0.74; 0.93]), antianginal (HR: 0.84 [0.74-0.96]), and cardiac glycoside therapy (HR: 0.69 [0.56-0.84]). LTPA was non-linearly related to a delayed initiation of glucose-lowering, antihypertensive, statin, fibrate, antiplatelet, antianginal, and cardiac glycoside therapy (minimum risk: 180-360 metabolic equivalents of task-min/day). Both combined were synergistically associated with a decreased onset of glucose-lowering drugs (p-interaction = 0.04), antihypertensive drugs (p-interaction < 0.001), vitamin K antagonists (p-interaction = 0.04), and cardiac glycosides (p-interaction = 0.01). Summarizing, sustained adherence to a MedDiet and LTPA were associated with lower risk of initiating cardiovascular-related medications.
• dc.format.mimetype application/pdf
• dc.identifier.citation Ribó-Coll M, Castro-Barquero S, Lassale C, Sacanella E, Ros E, Toledo E, Sorlí JV, Díaz-López A, Lapetra J, Muñoz-Bravo C, Arós F, Fiol M, Serra-Majem L, Pinto X, Castañer O, Fernández-Lázaro CI, Portolés O, Babio N, Estruch R, Hernáez Á. Mediterranean diet and physical activity decrease the initiation of cardiovascular drug use in high cardiovascular risk individuals: a cohort study. Antioxidants (Basel). 2021;10(3):397. DOI: 10.3390/antiox10030397
• dc.identifier.doi http://dx.doi.org/10.3390/antiox10030397
• dc.identifier.issn 2076-3921
• dc.identifier.uri http://hdl.handle.net/10230/48349
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof Antioxidants (Basel). 2021;10(3):397
• dc.rights © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Antianginal drugs
• dc.subject.keyword Antihypertensive drugs
• dc.subject.keyword Antiplatelet drugs
• dc.subject.keyword Cardiac glycosides
• dc.subject.keyword Fibrates
• dc.subject.keyword Glucose-lowering drugs
• dc.subject.keyword Mediterranean diet
• dc.subject.keyword Physical activity
• dc.subject.keyword Statins
• dc.subject.keyword Vitamin K epoxide reductase inhibitors
• dc.title Mediterranean diet and physical activity decrease the initiation of cardiovascular drug use in high cardiovascular risk individuals: a cohort study
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion