Genetic origins, singularity, and heterogeneity of Basques

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• dc.contributor.author Flores Bello, André, 1992-
• dc.contributor.author Bauduer, Frédéric
• dc.contributor.author Salaberria, Jasone
• dc.contributor.author Oyharçabal, Bernard
• dc.contributor.author Calafell i Majó, Francesc
• dc.contributor.author Bertranpetit, Jaume, 1952-
• dc.contributor.author Quintana Murci, Lluis
• dc.contributor.author Comas, David, 1969-
• dc.date.accessioned 2022-01-24T07:43:15Z
• dc.date.issued 2021
• dc.description.abstract Basques have historically lived along the Western Pyrenees, in the Franco-Cantabrian region, straddling the current Spanish and French territories. Over the last decades, they have been the focus of intense research due to their singular cultural and biological traits that, with high controversy, placed them as a heterogeneous, isolated, and unique population. Their non-Indo-European language, Euskara, is thought to be a major factor shaping the genetic landscape of the Basques. Yet there is still a lively debate about their history and assumed singularity due to the limitations of previous studies. Here, we analyze genome-wide data of Basque and surrounding groups that do not speak Euskara at a micro-geographical level. A total of ∼629,000 genome-wide variants were analyzed in 1,970 modern and ancient samples, including 190 new individuals from 18 sampling locations in the Basque area. For the first time, local- and wide-scale analyses from genome-wide data have been performed covering the whole Franco-Cantabrian region, combining allele frequency and haplotype-based methods. Our results show a clear differentiation of Basques from the surrounding populations, with the non-Euskara-speaking Franco-Cantabrians located in an intermediate position. Moreover, a sharp genetic heterogeneity within Basques is observed with significant correlation with geography. Finally, the detected Basque differentiation cannot be attributed to an external origin compared to other Iberian and surrounding populations. Instead, we show that such differentiation results from genetic continuity since the Iron Age, characterized by periods of isolation and lack of recent gene flow that might have been reinforced by the language barrier.
• dc.format.mimetype application/pdf
• dc.identifier.citation Flores-Bello A, Bauduer F, Salaberria J, Oyharçabal B, Calafell F, Bertranpetit J, Quintana-Murci L, Comas D. Genetic origins, singularity, and heterogeneity of Basques. Curr Biol. 2021;31(10):2167-77.e4. DOI: 10.1016/j.cub.2021.03.010
• dc.identifier.doi http://dx.doi.org/10.1016/j.cub.2021.03.010
• dc.identifier.issn 0960-9822
• dc.identifier.uri http://hdl.handle.net/10230/52292
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Curr Biol. 2021;31(10):2167-77.e4
• dc.rights © Elsevier http://dx.doi.org/10.1016/j.cub.2021.03.010
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Basques
• dc.subject.keyword Euskara
• dc.subject.keyword Franco-Cantabrian
• dc.subject.keyword Demographic history
• dc.subject.keyword Genome-wide data
• dc.subject.keyword Isolated population
• dc.subject.keyword Population structure
• dc.title Genetic origins, singularity, and heterogeneity of Basques
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion