ROS1 copy number alterations are frequent in non-small cell lung cancer
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- dc.contributor.author Clavé Safont, Sergica
- dc.contributor.author Gimeno Beltran, Javierca
- dc.contributor.author Muñoz-Mármol, Ana M.ca
- dc.contributor.author Vidal Barrull, Joanaca
- dc.contributor.author Reguart, Noemíca
- dc.contributor.author Carcereny, Enricca
- dc.contributor.author Pijuan Andujar, Laraca
- dc.contributor.author Menendez Romero, Silviaca
- dc.contributor.author Taus García, Álvaroca
- dc.contributor.author Mate, José Luísca
- dc.contributor.author Serrano Figueras, Sergica
- dc.contributor.author Albanell Mestres, Joanca
- dc.contributor.author Espinet Solà, Blancaca
- dc.contributor.author Arriola Aperribay, Edurneca
- dc.contributor.author Salido Galeote, Martaca
- dc.date.accessioned 2016-04-27T08:20:11Z
- dc.date.available 2016-04-27T08:20:11Z
- dc.date.issued 2014
- dc.description.abstract OBJECTIVES: We aimed to determine the prevalence and partners of ROS1 rearrangements, to explore the correlation between FISH and IHC assays, and to investigate clinical implications of ROS1 copy number alterations (CNAs). METHODS: A total of 314 NSCLC patients were screened using ROS1 FISH break-apart probes. Of these, 47 surgical tumors were included in TMAs to analyze ROS1 heterogeneity assessed either by FISH and IHC, and chromosome 6 aneusomy. To characterize ROS1 partners, probes for CD74, EZR, SLC34A2 and SDC3 genes were developed. ROS1 positive FISH cases were screened also by IHC. RESULTS: Five patients were ROS1 positive (1.8%). We identified two known fusion partners in three patients: CD74 and SLC34A2. Four out of five ROS1 rearranged patients were female, never smokers and with adenocarcinoma histology. Rearranged cases were also positive by IHC as well. According to ROS1 CNAs, we found a prevalence of 37.8% gains/amplifications and 25.1% deletions. CONCLUSIONS: This study point out the high prevalence of ROS1 CNAs in a large series of NSCLC. ROS1 gains, amplifications and deletions, most of them due to chromosome 6 polysomy or monosomy, were heterogeneous within a tumor and had no impact on overall survival.ca
- dc.description.sponsorship This work was supported in part by a grant from (1) Fundació La Marató de TV3 (666/C/2013), from (2) Red Temática de Investigación Cooperativa en Cáncer (RD12/0036/0044), from (3) Instituto de Salud Carlos III FEDER (PT13/0010/0005), (4) from Xarxa de Bancs de Tumors (XBTC), (5) from Agència de Gestió d’Ajuts Universitaris i de Recerca (2014SGR740) and (6) from Fondo de Investigaciones Sanitarias (FIS-ISCIII) (PI13/00140).
- dc.format.mimetype application/pdfca
- dc.identifier.citation Clavé S, Gimeno J, Muñoz-Mármol AM, Vidal J, Reguart N, Carcereny E. et al. ROS1 copy number alterations are frequent in non-small cell lung cancer. Oncotarget. 2016 Feb 16;7(7):8019-28. doi: 10.18632/oncotarget.6921.ca
- dc.identifier.doi http://dx.doi.org/10.18632/oncotarget.6921
- dc.identifier.issn 1949-2553
- dc.identifier.uri http://hdl.handle.net/10230/26178
- dc.language.iso engca
- dc.publisher Impact Journalsca
- dc.relation.ispartof Oncotarget. 2016 Feb 16;7(7):8019-28
- dc.rights c) Clavé S, Gimeno J, Muñoz-Mármol AM, Vidal J, Reguart N, Carcereny E. et al. This is an open-acces article distributed under the http://creativecommons.org/licenses/by/3.0/, which permits unrestriected use, distribution, and reproduction in any medium, provided the original author and source are creditedca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri http://creativecommons.org/licenses/by/3.0/ca
- dc.subject.other Pulmons -- Càncerca
- dc.subject.other Cèl·lules cancerosesca
- dc.title ROS1 copy number alterations are frequent in non-small cell lung cancerca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca