Olive oil phenolic compounds' activity against age-associated cognitive decline: clinical and experimental evidence
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- dc.contributor.author Boronat Rigol, Anna, 1990-
- dc.contributor.author Serreli, Gabriele
- dc.contributor.author Rodríguez-Morató, Jose, 1987-
- dc.contributor.author Deiana, Monica
- dc.contributor.author Torre Fornell, Rafael de la
- dc.date.accessioned 2023-09-29T07:33:24Z
- dc.date.available 2023-09-29T07:33:24Z
- dc.date.issued 2023
- dc.description.abstract Epidemiological studies have shown that consuming olive oil rich in phenolic bioactive compounds is associated with a lower risk of neurodegenerative diseases and better cognitive performance in aged populations. Since oxidative stress is a common hallmark of age-related cognitive decline, incorporating exogenous antioxidants could have beneficial effects on brain aging. In this review, we firstly summarize and critically discuss the current preclinical evidence and the potential neuroprotective mechanisms. Existing studies indicate that olive oil phenolic compounds can modulate and counteract oxidative stress and neuroinflammation, two relevant pathways linked to the onset and progression of neurodegenerative processes. Secondly, we summarize the current clinical evidence. In contrast to preclinical studies, there is no direct evidence in humans of the bioactivity of olive oil phenolic compounds. Instead, we have summarized current findings regarding nutritional interventions supplemented with olive oil on cognition. A growing body of research indicates that high consumption of olive oil phenolic compounds is associated with better preservation of cognitive performance, conferring an additional benefit, independent of the dietary pattern. In conclusion, the consumption of olive oil rich in phenolic bioactive compounds has potential neuroprotective effects. Further research is needed to understand the underlying mechanisms and potential clinical applications.
- dc.format.mimetype application/pdf
- dc.identifier.citation Boronat A, Serreli G, Rodríguez-Morató J, Deiana M, de la Torre R. Olive oil phenolic compounds' activity against age-associated cognitive decline: clinical and experimental evidence. Antioxidants (Basel). 2023 Jul 22;12(7):1472. DOI: 10.3390/antiox12071472
- dc.identifier.doi http://dx.doi.org/10.3390/antiox12071472
- dc.identifier.issn 2076-3921
- dc.identifier.uri http://hdl.handle.net/10230/57990
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof Antioxidants (Basel). 2023 Jul 22;12(7):1472
- dc.rights © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Cognitive decline
- dc.subject.keyword Cognitive performance
- dc.subject.keyword Extra virgin olive oil
- dc.subject.keyword Hydroxytyrosol
- dc.subject.keyword Neuroprotection
- dc.subject.keyword Olive oil
- dc.subject.keyword Phenolic bioactive compounds
- dc.subject.keyword Tyrosol
- dc.title Olive oil phenolic compounds' activity against age-associated cognitive decline: clinical and experimental evidence
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion