Impact of long-term exposure to ambient ozone on lung function over a course of 20 years (The ECRHS study): a prospective cohort study in adults

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• dc.contributor.author Zhao, Tianyu
• dc.contributor.author García Aymerich, Judith
• dc.contributor.author Heinrich, Joachim
• dc.date.accessioned 2023-12-11T06:37:22Z
• dc.date.available 2023-12-11T06:37:22Z
• dc.date.issued 2023
• dc.description.abstract Background: While the adverse effects of short-term ambient ozone exposure on lung function are well-documented, the impact of long-term exposure remains poorly understood, especially in adults. Methods: We aimed to investigate the association between long-term ozone exposure and lung function decline. The 3014 participants were drawn from 17 centers across eight countries, all of which were from the European Community Respiratory Health Survey (ECRHS). Spirometry was conducted to measure pre-bronchodilation forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) at approximately 35, 44, and 55 years of age. We assigned annual mean values of daily maximum running 8-h average ozone concentrations to individual residential addresses. Adjustments were made for PM2.5, NO2, and greenness. To capture the ozone-related change in spirometric parameters, our linear mixed effects regression models included an interaction term between long-term ozone exposure and age. Findings: Mean ambient ozone concentrations were approximately 65 μg/m³. A one interquartile range increase of 7 μg/m³ in ozone was associated with a faster decline in FEV1 of -2.08 mL/year (95% confidence interval: -2.79, -1.36) and in FVC of -2.86 mL/year (-3.73, -1.99) mL/year over the study period. Associations were robust after adjusting for PM2.5, NO2, and greenness. The associations were more pronounced in residents of northern Europe and individuals who were older at baseline. No consistent associations were detected with the FEV1/FVC ratio. Interpretation: Long-term exposure to elevated ambient ozone concentrations was associated with a faster decline of spirometric lung function among middle-aged European adults over a 20-year period. Funding: German Research Foundation.
• dc.description.sponsorship The present analyses are part of the Ageing Lungs in European Cohorts (ALEC) Study (www.alecstudy.org), which has also received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 633212. The local investigators and funding agencies for the European Community Respiratory Health are reported in the Supplementary Material.
• dc.format.mimetype application/pdf
• dc.identifier.citation Zhao T, Markevych I, Fuertes E, de Hoogh K, Accordini S, Boudier A, et al. Impact of long-term exposure to ambient ozone on lung function over a course of 20 years (The ECRHS study): a prospective cohort study in adults. Lancet Reg Health Eur. 2023 Sep 1;34:100729. DOI: 10.1016/j.lanepe.2023.100729
• dc.identifier.doi http://dx.doi.org/10.1016/j.lanepe.2023.100729
• dc.identifier.issn 2666-7762
• dc.identifier.uri http://hdl.handle.net/10230/58470
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Lancet Reg Health Eur. 2023 Sep 1;34:100729
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/633212
• dc.rights © 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Air pollution
• dc.subject.keyword Forced expiratory volume
• dc.subject.keyword Middle aged
• dc.subject.keyword NDVI
• dc.subject.keyword Spirometry
• dc.subject.keyword Vital capacity
• dc.title Impact of long-term exposure to ambient ozone on lung function over a course of 20 years (The ECRHS study): a prospective cohort study in adults
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion