Pancreatic cancer risk and levels of trace elements

Amaral, André F.S.; Porta Serra, Miquel; Silverman, Debra T.; Milne, Roger L.; Kogevinas, Manolis; Rothman, Nathaniel; Cantor, Kenneth P; Jackson, Brian P.; Pumarega Rodríguez, José Antonio; López, Tomàs; Carrato, Alfredo; Guarner, Luisa; Real, Francisco X.; Malats i Riera, Núria

Pancreatic cancer risk and levels of trace elements

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dc.contributor.author Amaral, André F.S.
dc.contributor.author Porta Serra, Miquel
dc.contributor.author Silverman, Debra T.
dc.contributor.author Milne, Roger L.
dc.contributor.author Kogevinas, Manolis
dc.contributor.author Rothman, Nathaniel
dc.contributor.author Cantor, Kenneth P
dc.contributor.author Jackson, Brian P.
dc.contributor.author Pumarega Rodríguez, José Antonio
dc.contributor.author López, Tomàs
dc.contributor.author Carrato, Alfredo
dc.contributor.author Guarner, Luisa
dc.contributor.author Real, Francisco X.
dc.contributor.author Malats i Riera, Núria
dc.date.accessioned 2019-02-11T08:44:31Z
dc.date.available 2019-02-11T08:44:31Z
dc.date.issued 2012
dc.description.abstract Background and Aims: Knowledge on the aetiology of exocrine pancreatic cancer (EPC) is scant. The best established risk factor for EPC is tobacco smoking. Among other carcinogens, tobacco contains cadmium, a metal previously associated with an increased risk of EPC. This study evaluated the association between concentrations of trace elements in toenails and EPC risk. Methods: The study included 118 EPC cases and 399 hospital controls from eastern Spain. Levels of 12 trace elements were determined in toenail samples by inductively coupled plasma mass spectrometry. OR and 95% CI, adjusted for potential confounders, were calculated using logistic regression. Results: Significantly increased risks of EPC were observed among subjects whose concentrations of cadmium (OR 3.58, 95% CI 1.86 to 6.88; ptrend=5×10−6), arsenic (OR 2.02, 95% CI 1.08 to 3.78; ptrend=0.009) and lead (OR 6.26, 95% CI 2.71 to 14.47; ptrend=3×10−5) were in the highest quartile. High concentrations of selenium (OR 0.05, 95% CI 0.02 to 0.15; ptrend=8×10−11) and nickel (OR 0.27, 95% CI 0.12 to 0.59; ptrend=2×10−4) were inversely associated with the risk of EPC. Conclusion: Novel associations are reported of lead, nickel and selenium toenail concentrations with pancreas cancer risk. Furthermore, the results confirm previous associations with cadmium and arsenic. These novel findings, if replicated in independent studies, would point to an important role of trace elements in pancreatic carcinogenesis.
dc.format.mimetype application/pdf
dc.identifier.citation Amaral AF, Porta M, Silverman DT, Milne RL, Kogevinas M, Rothman N et al. Pancreatic cancer risk and levels of trace elements. Gut. 2012;61(11):1583-8. DOI: 10.1136/gutjnl-2011-301086
dc.identifier.doi http://dx.doi.org/10.1136/gutjnl-2011-301086
dc.identifier.issn 0017-5749
dc.identifier.uri http://hdl.handle.net/10230/36543
dc.language.iso eng
dc.publisher BMJ Publishing Group
dc.relation.ispartof Gut. 2012; 61(11):1583-8
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.subject.keyword Pancreas
dc.subject.keyword Arsenic
dc.subject.keyword Cadmium
dc.subject.keyword Lead
dc.subject.keyword Selenium
dc.title Pancreatic cancer risk and levels of trace elements
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/acceptedVersion

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