IgE and high-affinity IgE receptor in chronic inducible urticaria, pathogenic, and management relevance

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• dc.contributor.author Giménez Arnau, Anna Maria
• dc.contributor.author Ribas-Llauradó, Clara
• dc.contributor.author Mohammad-Porras, Nasser
• dc.contributor.author Deza Vargas, Luis Gustavo
• dc.contributor.author Pujol Vallverdú, Ramon Maria
• dc.contributor.author Gimeno Martínez, Ramón
• dc.date.accessioned 2022-08-30T09:32:33Z
• dc.date.available 2022-08-30T09:32:33Z
• dc.date.issued 2022
• dc.description.abstract Background: IgE and high-affinity IgE receptor (FcεRI) expression on basophils have been scarcely explored in patients with chronic inducible urticaria (CIndU). Objectives: To investigate baseline serum IgE and FcεRI expression on blood basophils in a large cohort of CIndU patients and its relationship to treatment response. Methods: Baseline total serum IgE and basophil FcεRI expression measured by flow cytometry in 165 patients with CIndU was studied. The relationship of both parameters with the response to antihistamine and anti-IgE (omalizumab) treatment was considered in a subsample of CIndU patients. FcεRI expression in basophils was assessed by mean fluorescence intensity (MFI) and basophil FcεRI standardized density (receptors/cell). Results: The median FcεRI expression standardized per density in blood basophils was found significantly higher in patients with CIndU compared to HCs. A positive correlation was found between IgE serum levels and basophil FcεRI expression. Basal FcεRI expression was not related to antihistamine treatment response. However, it was related to omalizumab, and patients responding to omalizumab showed higher basal basophil expression of FcεRI levels. Non-responders to the antihistamine showed significantly higher IgE serum levels. Conclusions: FcεRI receptor overexpression in patients with CIndU shows almost the same pattern than chronic spontaneous urticaria. It seems to be independent of CIndU subtypes. Although additional studies would be welcome, our work highlights the relevance of FcεRI receptor regulation in CIndU supporting autoimmune basophil and mast cell activation and may be a biomarker for response to anti-IgE therapy.
• dc.format.mimetype application/pdf
• dc.identifier.citation Giménez-Arnau AM, Ribas-Llauradó C, Mohammad-Porras N, Deza G, Pujol RM, Gimeno R. IgE and high-affinity IgE receptor in chronic inducible urticaria, pathogenic, and management relevance. Clin Transl Allergy. 2022 Feb 1;12(2):e12117. DOI: 10.1002/clt2.12117
• dc.identifier.doi http://dx.doi.org/10.1002/clt2.12117
• dc.identifier.issn 2045-7022
• dc.identifier.uri http://hdl.handle.net/10230/53941
• dc.language.iso eng
• dc.publisher Wiley
• dc.relation.ispartof Clin Transl Allergy. 2022 Feb 1;12(2):e12117
• dc.rights © 2022 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword FcεRI receptor
• dc.subject.keyword IgE
• dc.subject.keyword Basophils
• dc.subject.keyword Chronic inducible urticaria
• dc.subject.keyword Omalizumab
• dc.title IgE and high-affinity IgE receptor in chronic inducible urticaria, pathogenic, and management relevance
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion